35395-28-9Relevant academic research and scientific papers
A Rapid and Highly Efficient Method for the Synthesis of Benzofulvenes via CsOH-Catalyzed Condensation of Indene and Aldehydes
Yi, Rongnan,Chen, Jinyang,Wang, Xueyan,Liang, Zhiwu,Xu, Xinhua
supporting information, p. 1347 - 1351 (2018/04/02)
A fast condensation of indene with a wide range of aldehydes catalyzed by cesium hydroxide monohydrate (CsOH·H2O) for the synthesis of benzofulvenes with good to excellent yields was demonstrated. The condensation can be completed within a few minutes under room temperature and air atmosphere without the use of special ligands or phase-transfer catalysts. In addition, the ratio of indene to aldehydes played an important role in this reaction. The single condensation products 3 can be obtained as main products with a ratio of 1.2:1, whereas the double condensation products 4 can be obtained by changing the ratio to 1:2.2. This protocol provides an efficient, simple and general method for the synthesis of benzofulvenes 3 and double condensation products 4, which are important intermediates in the synthesis of numerous drugs and natural products.
KF-Al2O3 induced condensations of indene with aromatic aldehydes
Lu, Wenxing,Zhu, Quan,Yan, Chao-Guo
, p. 3985 - 3990 (2007/10/03)
In the presence of KF-Al2O3 as a solid catalyst, indene reacted with aromatic aldehydes 2a-c (R=4-Me, 4-MeO, 4-Me2N) to yield mainly benzofulvenes 3a-c (45%-66%), while when treated with two molar of aromatic aldehydes 2d-
Condensation reactions in water of active methylene compounds with arylaldehydes. One-pot synthesis of flavonols
Fringuelli, Francesco,Pani, Giosanna,Piermatti, Oriana,Pizzo, Ferdinando
, p. 11499 - 11508 (2007/10/02)
The condensation reactions of acetophenone, cyclohexanone, isophorone, phenylacetonitrile, p-nitrophenylacetonitrile, (phenylsulfonyl)acetonitrile and indene with benzaldehyde were studied in water heterogeneous phase in the presence and absence of anionic and cationic surfactants such as SLS, CTACl, (CTA)2SO4 and CTAOH. All the reactions occur with excellent yields. The cationic surfactants favour the reaction and the comparison with the corresponding tetrabutylammonium salts show that the micellar catalysis is effective mainly towards the dehydration reaction following that of condensation. Anionic surfactant SLS is inactive. 2'-hydroxychalcones were prepared in aqueous medium in good-excellent yields and the one-pot synthesis of 7- and 3',4'-substituted flavonols was achieved.
ACTIVATION DE LA LIAISON C-H FAIBLEMENT ACIDE PAR ADSORPTION SUR KF-Al2O3
Villemin, Didier,Ricard, Michele
, p. 1059 - 1060 (2007/10/02)
Condesation of poorly acidic carbon compounds (pka 18-30) with benzaldehyde was achieved by adsorption without solvent on KF-Al2O3.KF-Al2O3 appears as a stronger base than KF.
