35408-57-2Relevant academic research and scientific papers
Decarboxylation of a Wide Range of Amino Acids with Electrogenerated Hypobromite
Matthessen, Roman,Claes, Laurens,Fransaer, Jan,Binnemans, Koen,De Vos, Dirk E.
, p. 6649 - 6652 (2014)
Bromide-assisted electrochemical decarboxylation efficiently produces valuable nitriles in high yields from a wide range of naturally occurring amino acids in a single step. Bromide salts are used as both redox mediators and supporting electrolytes in a simple one-compartment setup. As demonstrated for lysine, the selectivity of the decarboxylation can be tuned towards nitriles, amines or amides. An electrochemical system is developed that allows the selective decarboxylation of a wide range of amino acids. Valuable nitriles are obtained in high yields in a single step by using bromide salts as both redox mediators and supporting electrolytes. The product selectivity of lysine can be tuned towards nitriles, amines, or amides.
Organic catalytic L - lysine chemical decarboxylation preparation 1, 5 - pentanediamine method (by machine translation)
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Paragraph 0102-0107, (2020/06/17)
The invention provides an organic catalytic L - lysine chemical decarboxylation preparation 1, 5 -pentanediamine, and belongs to the field 1 and 5 -pentanediamine preparation methods. The method comprises L - lysine hydrochloride as a starting raw material, adding an alkali solution, carrying out neutralization reaction at room temperature, adding a solvent or L - lysine as a starting raw material, adding a solvent, adding hydrochloric acid and stirring reaction in an aqueous phase, stirring and reacting the solvent and washing with a solvent and obtaining 1 g 5 - pentanediamine. The method has the advantages of mild reaction conditions, simple operation, cheap and easily available catalyst and solvent, recyclable reutilization, low production cost, environmental friendliness, high product yield and suitability for large-scale preparation 1 and 5 - pentanediamine products. (by machine translation)
Method for production of 1,5-pentanediamine by chemical decarboxylation of L-lysine and separation and extraction method
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Paragraph 0029-0047, (2019/08/30)
The invention provides a method for production of 1,5-pentanediamine by chemical decarboxylation of L-lysine and a separation and extraction method. The method of the invention comprises the followingsteps: (1) dissolving L-lysine or L-lysine hydrochloride in a citric acid-disodium hydrogen phosphate buffer solution; (2) dropwise adding an oxidizer solution into the buffer solution obtained in the Step (1), and reacting at 10-75 DEG C for 20-30 min; and (3) adding transition metal salt into a reaction solution obtained in the Step (2), and simultaneously adding a reducing agent and mixing intensely and reacting for 20-120 min so as to obtain a 1,5-pentanediamine solution. According to the invention, L-lysine or its hydrochloride is used as a raw material to undergo an oxidative decarboxylation reaction and a cyan reduction reaction to obtain 1,5-pentanediamine. The reaction has mild conditions, is easy to operate and has good repeatability. By using cation exchange resin to contact with the 1,5-pentanediamine solution, the method of the invention is low-cost and environmentally-friendly in comparison with existing 1,5-pentanediamine separation methods.
