35434-71-0 Usage
General Description
Trimethyl-d8-amine is a deuterated form of trimethylamine, a colorless gas with a strong fishy odor. It is commonly used as a building block in the chemical industry for the synthesis of pharmaceuticals, pesticides, and polymers. Trimethyl-d8-amine is also utilized as a solvent for various reactions and serves as a precursor for the production of quaternary ammonium compounds. This chemical compound is classified as a hazardous substance due to its flammable and toxic nature, as well as its potential to cause skin and eye irritation. Proper handling and storage guidelines should be followed when working with trimethyl-d8-amine to ensure safety in the laboratory or industrial setting.
Check Digit Verification of cas no
The CAS Registry Mumber 35434-71-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,4,3 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 35434-71:
(7*3)+(6*5)+(5*4)+(4*3)+(3*4)+(2*7)+(1*1)=110
110 % 10 = 0
So 35434-71-0 is a valid CAS Registry Number.
35434-71-0Relevant articles and documents
Nonadditivity of secondary deuterium isotope effects on basicity of trimethylamine
Perrin, Charles L.,Dong, Yanmei
supporting information; experimental part, p. 11143 - 11148 (2009/02/05)
Secondary deuterium isotope effects (IEs) on basicities of isotopologues of trimethylamine have been accurately measured by an NMR titration method applicable to a mixture. Deuteration definitely increases the basicity, by ~0.021 in the ΔpK per D. The IE is attributed to the lowering of the CH stretching frequency and zero-point energy by delocalization of the nitrogen lone pair into the C-H antibonding orbital. Because this depends on the dihedral angle between the lone pair and the C-H, a further consequence is a preference for conformations with H antiperiplanar to the lone pair and D gauche. This leads to a predicted nonadditivity of IEs, which is confirmed experimentally. It is found that the decrease in basicity, per deuterium, increases with the number of deuteriums. The nonadditivity of IEs is a violation of the widely assumed Rule of the Geometric Mean.