35436-74-9

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 5137, 1950 DOI: 10.1021/ja01167a091

Upstream product

• 56-87-1 L-lysine 
• 357657-22-8 lysine acetylsalicylate 
• 50-78-2 aspirin 

Downstream Products

• 105707-01-5 diacetyllysine S-α-phenylethylamide 
• 181182-85-4 (R)-2-[2-((S)-2,6-Bis-acetylamino-hexanoylamino)-ethanesulfonylamino]-propionic acid benzyl ester 
• 181182-84-3 (S)-2,6-Bis-acetylamino-hexanoic acid 2-nitro-phenyl ester 

Relevant academic research and scientific papers

Aminoacid derivatives of cephalosporin compounds

Novel organic amide compounds which are N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl]cephalosporin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 7-aminocephalosporanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

Antibacterial amide compounds and means for using the same

Novel organic amide compounds which are N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl] penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)-phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino) phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.