354526-96-8

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 213316-20-2 1-(tert-butoxycarbonylamino)-3-cyclopentene-1-carboxylic acid 
• 354526-80-0 2-allyl-2-tert-butoxycarbonylamino-pent-4-enoic acid ethyl ester 
• 354526-82-2 2-allyl-2-tert-butoxycarbonylamino-pent-4-enoic acid 
• 154145-82-1 ethyl 2-allyl-2-aminopent-4-enoate 
• 207729-00-8 ethyl 1-((tert-butoxycarbonyl)amino)cyclopent-3-ene-1-carboxylate 
• 199532-88-2 ethyl 1-aminocyclopent-3-ene-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 952193-55-4 (2R)-5,5-diallyl-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine 
• 952193-59-8 C₁₅H₂₄N₂O₂ 
• 354526-85-5 2-(2-allyl-2-tert-butoxycarbonylamino-pent-4-enoylamino)-3-phenyl-propionic acid methyl ester 

Relevant academic research and scientific papers

Microwave assisted synthesis of spiro-2,5-diketopiperazines

A general and efficient method for the synthesis of spiro-2,5-diketopiperazines (spiro-DKPs) is described. Cyclization of Boc-protected dipeptides containing spiro-amino acids by microwave assisted heating in water furnished the corresponding spiro-DKPs. The spiro-amino acids were prepared by combining stereoselective alkylation reactions using the Sch?llkopf methodology for amino acid construction with Grubbs ring-closing metathesis (RCM) methodology using ruthenium complexes. The RCM reactions and all subsequent transformations to the spiro-DKPs were run with microwave assisted heating, resulting in high yields and short reaction times for all steps.

Modification of constrained peptides by ring-closing metathesis reaction

Ring-closing metathesis (RCM) with α,α-diallylglycyl peptides is shown to furnish α,α-cyclopentenylglycyl peptides as conformationally restrained analogues in the form of post-translational type peptide modification suitable for both peptidomimetic and co