354549-15-8

Upstream product

• 100-02-7 4-nitro-phenol 
• 13820-09-2 trimethyl orthovalerate 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 1043960-68-4 4-(2-butyl-4-oxoquinazolin-3-(4H)-yl)phenyl trifluoromethanesulfonate 
• 1043961-90-5 tert-butyl 3-(4-(2-butyl-4-oxoquinazolin-3(4H)-yl)phenoxy)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS

This invention is directed to compounds of formula (I): wherein (A), n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Efficient solid phase synthesis of diverse quinazolinones

Various quinazolinones were synthesized by cyclocondensation of anthranilamides with a variety of orthoformates on solid supports. Alkyl, aryl and alkoxy groups can substitute at 2 position of quinazolines with this method. The reactions proceeded smoothly under mild acidic conditions and the products exhibited excellent purity. Unlike previously reported solid phase quinazolinone syntheses, this synthetic strategy does not require an oxidation step. The approach is applicable to the synthesis of a wide range of quinazolinones, including molecules that are susceptible to oxidation.