3546-03-0 Usage
Chemical Properties
Greenish Yellow Solid
Originator
Terckian,Theraplix,France,1972
Uses
Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.
Manufacturing Process
The following is taken from US Patent 3,057,851. Milorganite was extracted
with water to obtain an aqueous extract containing vitamin B12 active
substances. This aqueous extract was purified by treatment with an ion
exchange resin according to the following method. An aqueous extract of
milorganite, 100 ml containing 300 μg of vitamin B12 active substances and
4.5 grams of total solids, was combined with 0.5 gram of sodium nitrite and
0.4 gram of potassium cyanide. The resulting solution was adjusted to pH 4.0
with hydrochloric acid and heated to boiling. The boiled solution was filtered
through a Super-Cel filter surface, and the filter was then washed with water.
The filtrate was obtained in a total volume of 130 ml including the washings.Amerlite XE-97, an ion exchange resin of the carboxyl type (Rohm and Haas),
was classified to an average wet particle size of 100 to 150 mesh. The
classified resin was utilized in the hydrogen form, and was not buffered during
the ion exchange fractionation. The classified resin, in the amount of 35 ml,
was packed into a glass column having a diameter of 25 mm and a height of
250 mm. The cyanide-treated aqueous extract of milorganite was infused
gravitationally into the ion exchange bed at a rate of 3 ml per minute.The effluent was discarded and the resin bed was then washed with the
following solutions in the specified sequence: (1) 120 ml of an aqueous 0.1 N
hydrochloric acid solution; (2) 75 ml of an aqueous 85% acetone solution;
and (3) 70 ml of an aqueous 0.1 N hydrochloric acid solution. After washing,
the resin bed was eluted with an aqueous 60% dioxane solution containing
0.1 N of hydrochloric acid. In this elution, 8 ml of colored eluate was
collected. This portion of the eluate was found to contain 295 μg of
cyanocobalamin and 9 mg of total solids.
Therapeutic Function
Tranquilizer
Check Digit Verification of cas no
The CAS Registry Mumber 3546-03-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,4 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3546-03:
(6*3)+(5*5)+(4*4)+(3*6)+(2*0)+(1*3)=80
80 % 10 = 0
So 3546-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
3546-03-0Relevant articles and documents
N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin
Singh, Gurmit,Koerner, Terry B.,Godefroy, Samuel Benrejeb,Armand, Claude
, p. 2160 - 2162 (2012)
A modified Polonovski reaction has been employed to obtain the N-demethylated metabolite of the neuroleptic drug cyamemazine. The synthesis involves N-oxide formation, isolation of the corresponding N-oxide, and a FeSO4·7H2O mediated Polonovski reaction to afford the desired monodesmethyl cyamemazine. In a subsequent step the hapten N-demethylcyamemazine-hemiglutarate was synthesized and its conjugated to bovine serum albumin (BSA).
Synthesis of deuterium-labeled cyamemazine and monodesmethyl cyamemazine
Bolla, R. Sekhar,Kasi Viswanath
, p. 82 - 85 (2014/03/21)
A novel approach is presented for the synthesis of cyamemazine maleate and N-desmethyl cyamemazine maleate using a 10-(amino-2-methylpropyl)phenothiazine derivative. This method was successfully applied to the synthesis of [ 2H6]cyamemazine maleate and N-desmethyl-[ 2H3]cyamemazine maleate.
An improved process for the preparation of pure cyamemazine and salts thereof
-
Page/Page column, (2014/07/09)
The present invention provides an improved process for the preparation of cyamemazine of formula-1 or its pharmaceutically acceptable salt thereof, which is substantially free of impurities.
