35486-97-6

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 99-96-7 4-hydroxy-benzoic acid 
• 106342-09-0 4-methoxycarbonylphenyl 2-tetrahydropyranyl ether 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 121-65-3 para-dodecylbenzenesulfonic acid 
• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 124-38-9 carbon dioxide 
• 203256-87-5 4-(Tetrahydro-pyran-2-yloxy)-benzoic acid benzyl ester 
• 94-18-8 Benzyl 4-hydroxybenzoate 

Downstream Products

• 99-96-7 4-hydroxy-benzoic acid 
• 724449-06-3 3,4'-biphenyl bis-4-(tetrahydropyran-2'-yloxy)benzoic acid 
• 50687-66-6 4-n-octyloxyphenyl 4-hydroxybenzoate 
• 119959-84-1 2-methyl-1,4-phenylene bis(4-hydroxybenzoate) 

Relevant academic research and scientific papers

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

The key role of RNA-binding proteins (RBPs) in regulating post-transcriptional processes and their involvement in several pathologies (i.e., cancer and neurodegeneration) have highlighted their potential as therapeutic targets. In this scenario, Embryonic Lethal Abnormal Vision (ELAV) or Hu proteins and their complexes with target mRNAs have been gaining growing attention. Compounds able to modulate the complex stability could constitute an innovative pharmacological strategy for the treatment of numerous diseases. Nevertheless, medicinal-chemistry efforts aimed at developing such compounds are still at an early stage. As part of our ongoing research in this field, we hereby present the rational design and synthesis of structurally novel HuR ligands, potentially acting as HuR-RNA interferers. The following assessment of the structural features of their interaction with HuR, combining saturation-transfer difference NMR and in silico studies, provides a guide for further research on the development of new effective interfering compounds of the HuR-RNA complex.

METHOD OF PRODUCING POLYMERIZABLE COMPOUND, AND SOLUTION OF POLYMERIZABLE COMPOUND

Disclosed is a method of producing a polymerizable compound that enables production of, in high yield, a polymerizable compound used for producing an optical film or the like. The disclosed method of producing a polymerizable compound comprises reacting a compound represented by formula (I) with a compound represented by formula (II) in an organic solvent in which a base having a pKa from 6.1 to 9.5 is present, so as to obtain a reaction solution containing a polymerizable compound represented by formula (III).

A BISPHENOL DERIVATIVE HAVING AN ESTER BOND

PROBLEM TO BE SOLVED: To provide a production intermediate useful for obtaining a compound having an ester bond, and a production method to obtain a compound having an ester bond, using the same, with convenience and high purity; specifically, to provide a bisphenol derivative having an ester bond, a method for producing the same, and a compound produced from the bisphenol derivative as an intermediate; and to further provide a polymer obtained by the polymerization of a polymerizable composition containing the compound produced from the bisphenol derivative as an intermediate, and an optical anisotropic body using the polymer. SOLUTION: A bisphenol derivative having an ester bond is represented by general formula (I-C), where at least one of A1 and A2 is substituted with one substituent L. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

CINNAMIC ACID DERIVATIVE, POLYMER THEREOF, AND LIQUID CRYSTAL ALIGNMENT LAYER COMPRISING CURED ARTICLE THEREOF

Provided is a liquid crystal alignment layer of which a constituent member is a compound represented by the general formula (I).

Additive components for liquid crystalline materials

The present invention relates to mesogenic, cross-linkable mixtures comprising (i) a cross-linkable liquid crystalline host compound comprising at least one cross-linkable liquid crystalline compound, and (ii) at least one chiral or achiral rod shaped additive component, wherein said additive component has a rigid core and comprises at least two fused or linked, optionally substituted, non-aromatic, aromatic, carbocyclic or heterocyclic groups, and also comprises at least one optionally substituted alkyl residue, and at least one polymerizable group and wherein the additive component has a transition temperature to the isotropic state of 40° C. or lower. The invention also relates to the novel chiral or achiral rod-shaped additive compounds used for the preparation of these mixtures, to mixtures according to the invention in form of an elastomer, polymer gel, polymer network or polymer film, to polymer networks and liquid crystalline polymer films prepared from these mixtures and to optical or electrooptical components comprising polymer networks and liquid crystalline polymer films prepared from such mixtures. Further, the invention relates to the use of the chiral or achiral rod shaped compounds as components of a cross-linkable liquid crystalline mixture in the production of orientated liquid crystalline polymers, to liquid crystalline mixtures comprising these compounds, to liquid crystalline polymers and liquid crystalline polymer networks prepared from such liquid crystalline mixtures, and to liquid crystalline devices comprising these compounds.

Process for the carboxylation of aryl halides with palladium catalysts

A process for the carboxylation of an aryl halide to yield an aryl carboxylic acid, in which the aryl halide and CO2 are contacted in an organic solvent under inert atmosphere and in the presence of a reducing agent and an adequate catalyst system.

MESOGEN CONTAINING COMPOUNDS

Compounds including at least one mesogenic substructure and at least one long flexible segment and methods of synthesizing the same are disclosed. Formulations which include various embodiments of the mesogen containing compounds and their use in articles of manufacture and ophthalmic devices are also disclosed.

Palladium-catalyzed direct carboxylation of aryl bromides with carbon dioxide

(Chemical Equation Presented) A novel protocol for the direct carbon dioxide insertion (CO2) into aryl halides in a catalytic manner is presented herein. Unlike other carboxylation methods using CO2, there is no need for the synthesis of the corresponding organometallic intermediates. Additionally, and in contrast to the well-established carbonylation processes, our protocol does not use highly toxic CO for the preparation of benzoic acids. Furthermore, this method is distinguished by its mild conditions, allowing the tolerance of a wide range of functional groups and substitution patterns. The crucial step of the process involves a challenging catalytic CO2 insertion into Pd-C bonds. Copyright

Influence of helical twisting power on the photoswitching behavior of chiral azobenzene compounds: Applications to high-performance switching devices

Five photochromic chiral azobenzene compounds and one nonphotochromic chiral compound were synthesized and characterized by IR, 1H NMR spectroscopy, and elemental analysis. Cholesteric liquid crystalline phases were induced by mixing of the non

Photochromic compounds

Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other non-limiting embodiments relate to photochromic-dichroic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. For example, one non-limiting embodiment provides a thermally reversible, photochromic compound adapted to have at least a first state and a second state, wherein the thermally reversible, photochromic compound has an average absorption ratio greater than 2.3 in at least one state as determined according to CELL METHOD. Another non-limiting embodiment provides a photochromic compound comprising: (a) at least one photochromic group chosen from a pyran, an oxazine, and a fulgide; and (b) at least one lengthening agent L attached to the at least one photochromic group and represented by the formula —[S1]c-[Q1-[S2]d]d′-[Q2-[S3]e]e′-[Q3-[S4]f]f′—S5—P, which is described herein.