35491-57-7Relevant academic research and scientific papers
N-Heterocyclic Carbene-Catalyzed Convenient Benzonitrile Assembly
Jia, Qianfa,Wang, Jian
, p. 2212 - 2215 (2016)
The benzonitrile unit is widely found in natural products, pharmaceuticals, and agrochemicals. Synthesis of benzonitriles has received considerable interests from the chemical community over the last few decades. Present synthetic protocols mainly rely on the pre-existing benzene core to install a cyano moiety. A new NHC-catalyzed [4 + 2]-benzannulation protocol is reported to assemble the benzonitrile framework.
Base-Promoted Tandem Cyclization for the Synthesis of Benzonitriles by C?C Bond Construction
Zhu, Cheng-Zhi,Wei, Yin,Shi, Min
supporting information, p. 808 - 813 (2018/01/27)
A facile synthesis of benzonitriles via a base-promoted tandem cyclization reaction of α,β-unsaturated enones having electron-withdrawing group (EWG) and 2-acyl-acrylonitriles was developed. This new synthetic method to access benzonitriles is suitable for a wide range of substrates. A plausible reaction mechanism is proposed on the basis of previous literature and our own investigations. (Figure presented.).
Phosphine-catalyzed addition/cycloaddition domino reactions of β′-Acetoxy allenoate: Highly stereoselective access to 2-oxabicyclo[3.3.1]nonane and Cyclopenta[a]pyrrolizine
Gu, Yiting,Hu, Pengfei,Ni, Chunjie,Tong, Xiaofeng
supporting information, p. 6400 - 6406 (2015/06/02)
Two classes of phosphine-catalyzed addition/cycloaddition domino reactions of β′-acetoxy allenoate 1 have been developed. The reaction of 1 with 2-acyl-3-methyl-acrylonitrile 2 readily occurs to give 2-oxabicyclo[3.3.1]nonane 3, furnishing the β′-addition
Allosteric modulators of the adenosine A1 receptor: Synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes
Aurelio, Luigi,Valant, Celine,Flynn, Bernard L.,Sexton, Patrick M.,Christopoulos, Arthur,Scammells, Peter J.
experimental part, p. 4543 - 4547 (2010/02/28)
A series of 4-substituted 2-amino-3-benzoylthiophenes was screened using a functional assay of A1ARmediated phosphorylation of ERK1/2 in intact CHO cells to identify both potential agonistic effects as well the ability to allosterically modulate the activ
Synthesis and pharmacological evaluation of 2,3 dihydro 1H thieno[2,3 e][1,4]diazepines
Tinney,Sanchez,Nogas
, p. 624 - 630 (2007/10/05)
A series of 2,3 dihydro 1H thieno[2,3 e][1,4]diazepines was synthesized and evaluated for CNS activity. A new antianxiety screen for benzodiazepine like drugs was used along with the standard anticonvulsant test. Structure activity relationships are discussed. One compound, 1,3,6,7,8,9 hexahydro 5 phenyl 2H [1]benzothieno[2,3 e][1,4]diazepin 2 one monosulfate (CI 718), is undergoing clinical studies in man.
