355-30-6

Usage

Uses

Used in Pharmaceutical Manufacturing:
NONAFLUOROPENTALDEHYDE HYDRATE is used as a key intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones.
Used in Specialty Chemical Production:
It is utilized as a reactant in the preparation of other fluorinated compounds, enhancing the properties of specialty chemicals for various applications.
Used in the Synthesis of Fluorinated Building Blocks:
NONAFLUOROPENTALDEHYDE HYDRATE is employed as a precursor in the synthesis of fluorinated building blocks, which are essential for creating new chemical entities with unique properties.
Used in Materials Science:
It is used as a component in the development of advanced materials, leveraging its strong oxidizing nature to create materials with novel characteristics for various industries.
Used in Nanotechnology:
NONAFLUOROPENTALDEHYDE HYDRATE is used in nanotechnology applications, where its reactivity and ability to form fluorinated compounds contribute to the creation of nanoscale materials with specific functionalities.
Overall, NONAFLUOROPENTALDEHYDE HYDRATE is a valuable and versatile chemical, playing a crucial role in the field of organic synthesis and specialty chemical manufacturing, with potential applications spanning across pharmaceuticals, materials science, and nanotechnology.

InChI:InChI=1/C5HF9O/c6-2(7,1-15)3(8,9)4(10,11)5(12,13)14/h1H

Upstream product

• 424-36-2 2,2,3,3,4,4,5,5,5-nonafluoropentanoic acid ethyl ester 
• 423-39-2 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane 
• 68-12-2 N,N-dimethyl-formamide 
• 2706-90-3 Perfluoropentanoic acid 

Downstream Products

• 375-53-1 perfluoropentanal 

Relevant academic research and scientific papers

SnX2/Al-promoted formylation of per(poly)fluoroalkyl halides with N,N-dimethylformamide

In the presence of catalytic amounts of stannous salts (20 molpercent) and aluminium powder, per(poly)fluoroalkyl iodides or bromides react smoothly with DMF under mild conditions to give the corresponding per(poly)fluoroalkyl aldehydes in good to excellent yield.A tin-containing intermediate was obtained.A possible mechanism is proposed.

Asymmetric synthesis of quaternary α-fluoro-β-keto-amines via detrifluoroacetylative Mannich reactions

Efficient asymmetric detrifluoroacetylative Mannich addition reactions between 2-fluoro-1,3-di-ketones/hydrates and chiral N-sulfinyl-imines via C-C bond cleavage were reported, which afforded C-F quaternary α-fluoro-β-keto-amines with excellent yields and high diastereoselectivity.

Organofluorine compounds and fluorinating agents part 17: Sonochemical-forced preparation of perfluoroalkanals and their use for non-conventional acetalations of carbohydrates 1, 2

The homologous 1-iodo-perfluoroalkanes 1a-1c and α,ω-dibromo-perfluoroalkanes 4a, 4b were carbonylated with DMF in the presence of Al/SnCl2 or Al/PbBr2 under sonication in a short reaction time. The hydrated aldehydes 2a-2c and 5a, 5b respectively were obtained in good yields allowing dehydration to 3a-3c and 6a, 6b. Some of the fluorinated aldehydes were selected as substrates in a Wittig-Horner olefination assisted by ultrasound and in non-conventional acetalations of methyl α-L-rhamnopyranoside (9). Thus, (E)-1-perfluorooctyl-2-phenylsulphonyl-ethene (8) was prepared from 3c and the phosphonate 7 by Wittig-Horner synthesis. Acetalations of 9 were carried out with the aldehydes (3a, 3b, 6a), hydrated aldehydes (2a, 2b), and the aldehyde hemiacetal 12 respectively, in the presence of dicyclohexylcarbodiimide (DCC). In all cases, a selective epimerization was observed at the C-atom 3 of the monosaccharide, i.e. polyfluoroalkylidenated 6-deoxy-α-L-altropyranosides 10, 11, 13, and 14 were obtained.