355024-58-7

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 85963-91-3 methyl 2-(4-nitrobenzoyl)-3-oxobutanoate 
• 1391908-11-4 methyl 3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylate 
• 13524-04-4 2'-chloro-sec-phenethyl alcohol 
• 91135-88-5 3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylic acid 

Downstream Products

• 1391908-12-5 1-(2-chlorophenyl)ethyl(5-(4-aminophenyl)-3-methylisoxazol-4-yl)carbamate 
• 1391907-61-1 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate 

Relevant academic research and scientific papers

COMPOUND AS ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR, COMPOSITION, AND USE THEREOF

The present invention relates to a compound as antagonist of LPA receptor, and a pharmaceutical composition comprising the same. The present invention also relates to the use of the compound and the composition, and a method of using the compound to treat

COMPOUND AS ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR, COMPOSITION, AND USE THEREOF

The present invention discloses a compound as antagonist of LPA receptor, and a pharmaceutical composition comprising the same. The present invention also discloses the use of the compound and the composition, and a method of using the compound to treat, prevent or diagnose diseases, disorders or conditions associated with one or more of the LPA receptors.

Novel isoxazole and thiazole compounds and use thereof as drugs

The present invention relates to novel isoxazole and thiazole compounds having an excellent lysophosphatidic acid (LPA) receptor antagonistic activity represented by general formula [1] or salts thereof: wherein R1 and R2 represents an optionally substituted alkyl group or the like; R3 represents a hydrogen atom or the like; R4 represent a group selected from the group consisting of (I) optionally substituted phenyl, aryl, or heterocycle, (II) substituted or nonsubstituted alkyl, and (III) substituted or nonsubstituted alkenyl, alternatively, R3 and R4 may form a ring structure together with a carbon atom to which they bind; and X represents an oxygen atom or a sulfur atom, provided that, when R3 is a hydrogen atom, R4 represents a group other than methyl, and the use thereof as a medicine.