35507-35-8

Basic information

• Product Name: BIS(4-AMINOPHENYL)DISELENIDE
• Synonyms: BIS(4-AMINOPHENYL)DISELENIDE;4,4'-Diselenobisaniline;Bis(4-aminophenyl) perselenide
• CAS NO: 35507-35-8
• Molecular Formula: C₁₂H₁₂N₂Se₂
• Molecular Weight: 342.15708
• Mol File: 35507-35-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 79.5 °C (decomp)
• Boiling Point: 501.8±60.0 °C(Predicted)
• Appearance: /
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: BIS(4-AMINOPHENYL)DISELENIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(4-AMINOPHENYL)DISELENIDE(35507-35-8)
• EPA Substance Registry System: BIS(4-AMINOPHENYL)DISELENIDE(35507-35-8)

Safety Data

• Hazardous Substances Data: 35507-35-8(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 540-37-4 p-aminoiodobenzene 
• 10336-11-5 4-aminophenylselenocyanate 
• 19188-18-2 p-nitrophenyl selenocyanate 
• 244047-82-3 4-aminobenzeneselenol 
• 51694-22-5 ortho-nitrophenyl selenocyanate 
• 36297-89-9 1,2-bis(4-nitrophenyl)diselane 

Downstream Products

• 1579196-45-4 N,N'-(diselanediyldibenzene-4,1-diyl)bis[4-(trifluoromethyl)benzenesulfonamide] 

Relevant articles and documents

Synthesis and X-ray structural characterization of Di-p-aminobenzenediselenide [p-H2NC6H4Se]2 and its mercury(II) derivatives

A synthetic route to obtain [p-H2NC6H4Se]2 (1) in good yield was developed, and the crystal structure of the product was characterized for the first time. The synthesis and structure of the mercury(II) derivativ

New amides containing selenium as potent leishmanicidal agents targeting trypanothione reductase

Two new series of 28 selenocyanate and diselenide derivatives containing amide moieties were designed, synthesized, and evaluated for their leishmanicidal activity against Leishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1

Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma

Nineteen organoselenides were synthesized and tested for their intrinsic cytotoxicity in hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines and their corresponding selective cytotoxicity (SI) was estimated using normal lung fibroblast (WI-38) cells. Most of the organic selenides exhibited good anticancer activity, and this was more pronounced in HepG2 cells. Interestingly, the naphthoquinone- (5), thiazol- (12), and the azo-based (13) organic selenides demonstrated promising SI (up to 76). Furthermore, the amine 4c, naphthoquinone 5, and azo-based 13 and 15 organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. Moreover, most of the synthesized candidates manifested good free radical-scavenging and GPx-like activities comparable to vitamin C and ebselen. The obtained results suggested that some of the presented organoselenium candidates have promising anti-HepG2 and antioxidant activities.