355126-33-9Relevant academic research and scientific papers
Inhibitors of prenyl-protein transferase
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, (2008/06/13)
The present invention comprises piperazinone-containing compounds which inhibit prenyl-protein transferases, including famesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.
Inhibitors of prenyl-protein transferase
-
, (2008/06/13)
The present invention comprises piperazinone-containing compounds, which may be useful as inhibitors of prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Bergman, Jeffrey M,Abrams, Marc T,Davide, Joseph P,Greenberg, Ian B,Robinson, Ronald G,Buser, Carolyn A,Huber, Hans E,Koblan, Kenneth S,Kohl, Nancy E,Lobell, Robert B,Graham, Samuel L,Hartman, George D,Williams, Theresa M,Dinsmore, Christopher J
, p. 1411 - 1415 (2007/10/03)
A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity in vitro and are promising agents for the inhibition of
