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• 1220392-97-1 N²,N²-dimethyl-N⁴,6-diphenyl-1,3,5-triazine-2,4-diamine 

Relevant academic research and scientific papers

Highly Efficient and Recyclable Porous Organic Polymer Supported Iridium Catalysts for Dehydrogenation and Borrowing Hydrogen Reactions in Water

Benzothiazole-doped porous organic polymers (POP-MBTS) were synthesized from a copolymerization reaction of 2-(6-(4-vinylphenyl)pyridin-2-yl)benzo[d]thiazole with divinylbenzene. The corresponding POP-MBTS-Ir was obtained and fully characterized using SEM, TEM, EDS, TGA, XPS, and N2 sorption isotherms, which disclosed that this catalyst has a high surface area, hierarchical porosity, and thermodynamic stability. Importantly, this catalyst revealed a high catalytic activity for ten different kinds of borrowing hydrogen and dehydrogenation reactions in water with a good recovery performance. Furthermore, mechanistic investigations were conducted for the synthesis of triazine derivatives.

2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof

The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.

Biguanide-based synthesis of 1,3,5-triazine derivatives with anticancer activity and 1,3,5-triazine incorporated calcium citrate nanoparticles

Twelve derivatives of biguanide-derived 1,3,5-triazines, a promising class of anticancer agent, were synthesised and evaluated for their anticancer activity against two colorectal cancer cell lines—HCT116 and SW620. 2c and 3c which are the derivatives con

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

Iridium Supported on Phosphorus-Doped Porous Organic Polymers: Active and Recyclable Catalyst for Acceptorless Dehydrogenation and Borrowing Hydrogen Reaction

Iridium-on-phosphorus-doped porous organic polymers (POP?Ir) were developed by anchoring simple iridium onto the skeleton of porous organic polymers through coordination bonds. This POP?Ir catalyst, which was thoroughly characterized by means of EDS, SEM, TEM, XRD, XPS, and FT-IR, revealed excellent catalytic activity for the reaction of diphenyl phosphinamide with benzyl alcohols through borrowing hydrogen strategy and acceptorless dehydrogenation with wide functional group tolerance. Moreover, this POP?Ir catalyst could be simply recovered and reused for at least five times without a significant loss of activity, and revealed considerable application prospects. The mechanism was investigated to further understand this POP?Ir catalytic system and transformations. Overall, the POP?Ir catalytic system has shown high activity and reusability in the borrowing hydrogen reaction between diphenyl phosphinamides and benzyl alcohols. (Figure presented.).

Aryl-substituted sulfonamide compound, preparation method and application thereof

The invention provides an aryl-substituted sulfonamide compound shown in a formula (II), a preparation method and an application thereof. The preparation method comprises the following steps: mixing a triazine compound shown in a formula (I) and para tolu

2,4-diamine-1,3,5-triazine compound, preparation method and application thereof

The invention provides a 2,4-diamine-1,3,5-triazine compound represented as the formula (III). A preparation method includes the following steps: adding compounds represented as the formulas (I) and (II), a metal copper catalyst, a ligand, an alkaline sub

Ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides

An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated benzyl alcohol containing functionalities s

1-Chloro-1,3-bis(dimethylamino)-2-azapropenylium Salts: Intermediates for the Synthesis of 1,3,5-Triazines, Pyrimidines, Isoquinolines, Quinazolines, and a 1,3,5-Thiadiazinium Salt

The title salts, which are formed by the action of dimethylcyanamide on the phosphorus oxychloride complexes of a variety of tertiary amides, are useful precursors of six-membered heteroaromatic compounds: they react with simple amidines to yield 1,3,5-triazines and with N,N-dimethylamidines to give pyrimidines; 3-arylmethyl-1-chloro-1,3-bis(dimethylamino)-2-azapropenylium perchlorates form isoquinolines, the related 3-arylamino-1-chloro-1-dimethylamino-2-azapropenylium salts cyclise to quinazolinium salts, and treatment of 1-chloro-1,3-bis(dimethylamino)-3-phenyl-2-azapropenylium perchlorate with potassium thiocyanate results in a rearranged 1,3,5-thiadiazinium salt.