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Upstream product

• 2453-44-3 3-Phenyl-2-propen-1-one 
• 40240-62-8 1-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)pyridin-1-ium bromide 
• 81878-54-8 1-biphenyl-4'-yl-3-phenylprop-2-enone 
• 72666-55-8 (4-Phenylphenacyl)isoquinolinium bromide 
• 108-88-3 toluene 
• 92-91-1 biphenyl-4-acetaldehyde 
• 100-46-9 benzylamine 
• 75408-89-8 4-acetylbiphenyl oxime 

Relevant academic research and scientific papers

Synthesis of Polyfunctional Pyridines via Copper-Catalyzed Oxidative Coupling Reactions

An efficient and concise approach for the synthesis of polysubstituted pyridines has been achieved through copper-catalyzed oxidative sp3 C-H coupling of oxime acetates with toluene derivatives. Besides, benzylamine and p-toluenesulfonylhydrazo

TMSOTf-mediated Kr?hnke pyridine synthesis using HMDS as the nitrogen source under microwave irradiation

An efficient protocol for the preparation of pyridine skeletons has been successfully developed involving the TMSOTf/HMDS (trifluoromethanesulfonic acid/hexamethyldisilane) system for the intermolecular cyclization of chalcones under MW (microwave) irradiation conditions. This method provides a facile approach to synthesize 2,4,6-triaryl or 3-benzyl-2,4,6-triarylpyridines in good to excellent yields. Interestingly, the 2,6-diazabicyclo[2.2.2]oct-2-ene core was obtained by changing the acid additive to Sn(OTf)2, and the desired product was also confirmed using X-ray single-crystal diffraction analysis.

Merrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines

Metal-free, base-free, biomimetic and chemoselective synthesis of 2,4,6-trisubstituted pyridines was developed under mild conditions for the first time. The heterogeneous biomimetic catalyst-recoverable Merrifield resin-supported quinone-was fully characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectrometry (XPS) and energy dispersive X-ray spectroscopy (EDX). This supported quinone catalyst exhibited excellent catalytic reactivity for chemoselective synthesis of 2,4,6-trisubstituted pyridines, providing an efficient and green method for the synthesis of pyridine derivatives under mild conditions. Mechanistic investigations were conducted to gain insights into the heterogeneous biomimetic catalyst as well as the resulting transformation. The successful capture of intermediates offered direct and clear evidence for the proposed mechanism.

Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes

A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl3 catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridines in high yields in the absence of any additive. A gram-scale reaction sequence was performed to demonstrate the scaled-up applicability of this synthetic method.

Metal-Free Synthesis of 2,4,6-Trisubstituted Pyridines via Iodine-Initiated Reaction of Methyl Aryl Ketones with Amines under Neat Heating

A neat heating protocol has been developed for metal-free synthesis of various 2,4,6-trisubstituted pyridines via iodine-initiated (in situ generated HI-catalyzed) condensation of methyl aryl ketones with amines and the following cyclization-aerobic oxidation. Large-scale synthesis and mechanistic investigation were also performed.

OLIGOPHENYLENE 2,4,6-TRIARYLPYRIDINES AND ANALOGOUS DIAZA-p-TERPHENYLS, DIAZA-p-QUATERPHENYLS AND DIAZA-p-QUINQUEPHENYLS WITH LUMINISCENT ACTIVITY

Cyclocondensation of α,β-unsaturated aromatic ketones V and VIII with quaternary pyridinium salts VI in the presence of ammonium acetate gave 2,4,6-triarylpyridines I, aryl-substituted diaza-p-terphenyls IIa,b, diaza-p-quaterphenyls IIc,d and diaza-p-quinquephenyls IIe,f.All the new polyphenylene compounds exhibit characteristic luminiscence in the visible spectral region.

Studies on Cycloimmonium Ylides. Synthesis of Some 2,4,6-Triaryl-Substituted Pyridines via Isoquinolinium Ylides

(Aroylmethylene)isoquinolinium ylides on their reaction with different α,β-unsaturated ketones gave a wide variety of 2,4,6-triaryl-substituted pyridines which are expected to possess some potential biological activities.The reaction seemed to proceed via