2453-44-3

Usage

Class

Chalcone class of organic compounds

Physical State

Yellow solid

Usage

Commonly used in the synthesis of various natural and synthetic compounds with potential pharmacological properties

Biological Activities

a. Antioxidant
b. Anti-inflammatory
c. Anticancer
d. Antiviral
e. Antimicrobial

Potential Applications

Studied for their potential use as drug candidates for the treatment of various diseases

Fields of Interest

Chemistry, biochemistry, and pharmaceutical sciences

InChI:InChI=1/C21H16O/c22-21(16-11-17-7-3-1-4-8-17)20-14-12-19(13-15-20)18-9-5-2-6-10-18/h1-16H/b16-11+

Upstream product

• 92-91-1 biphenyl-4-acetaldehyde 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 3218-36-8 4-Phenylbenzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 98-80-6 phenylboronic acid 
• 100-42-5 styrene 
• 19710-56-6 hydroxycarbene 
• 5122-94-1 4-biphenylboronic acid 
• 92-52-4 biphenyl 

Downstream Products

• 97157-03-4 1-biphenyl-4-yl-3-(2-morpholin-4-yl-ethylsulfanyl)-3-phenyl-propan-1-one 
• 96175-26-7 1-biphenyl-4-yl-4-nitro-3,4-diphenyl-butan-1-one 
• 43008-86-2 4-(3-Phenyl-propyl)-biphenyl 
• 43008-78-2 1-([1,1'-biphenyl]-4-yl)-3-phenylpropan-1-one 
• 140845-99-4 2-Biphenyl-4-yl-4-phenyl-1,4-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 86516-90-7 6-Biphenyl-4-yl-1,3-dimethyl-8-phenyl-7,8-dihydro-1H-pyrimido[4,5-b][1,4]oxazepine-2,4-dione 
• 3557-67-3 2,6-di([1,1'-biphenyl]-4-yl)-4-phenylpyridine 
• 3557-65-1 2-biphenyl-4-yl-4,6-diphenyl-pyridine 
• 122504-26-1 2-Biphenyl-4-yl-4-phenyl-6-[1,1';4',1'']terphenyl-4-yl-pyridine 
• 51813-19-5 3-([1,1'-biphenyl]-4-yl)-5-phenylisoxazole 
• 76287-94-0 3-(biphenyl-4-yl)-5-phenyl-4,5-dihydroisoxazole 
• 1017240-30-0 3-(biphenyl-4-yl)-5-phenyl-4,5-dihydro-1H-pyrazole 
• 28621-95-6 3-(3-Biphenyl-4-yl-3-oxo-1-phenyl-propyl)-4-hydroxy-chromen-2-one 
• 30313-29-2 4-Biphenyl-4-yl-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Rh(II)-Catalyzed Nitrene-Transfer [5 + 1] Cycloadditions of Aryl-Substituted Vinylcyclopropanes

Formal [5 + 1] cycloadditions between aryl-substituted vinylcyclopropanes and nitrenoid precursors are reported. The method, which employs Rh2(esp)2 as a catalyst, leads to the highly regioselective formation of substituted tetrahydropyridines. Preliminary mechanistic studies support a stepwise, polar mechanism enabled by the previously observed Lewis acidity of Rh-nitrenoids. Overall, this work expands the application of nitrene-transfer cycloaddition, a relatively underexplored approach to heterocycle synthesis, to the formation of six-membered rings.

Synthesis and characterization of 2-phenylpyrazoline derivatives and evaluation of their activities against antimicrobial and breast cancer cell line in vitro and in silico studies

The new series of 2-phenylpyrazoline derivatives (2a-j) were synthesized and evaluated for their antimicrobial, in silico and in vitro anticancer activity was performed by MTT assay using MDA-MB-231 (human breast adenocarcinoma) cell line. The 2-phenylpyr

Synthesis and characterization of 2-pyrazoline derivatives and their in silico and in vitro studies on antimicrobial and anticancer activities

The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-

Copper-Promoted Oxidative Intramolecular C–H Amination of Hydrazones to Synthesize 1H-Indazoles and 1H-Pyrazoles Using a Cleavable Directing Group

A facile and efficient synthesis of 1H-indazoles and 1H-pyrazoles through a copper-promoted oxidative intramolecular C–H amination of hydrazones using a cleavable directing group was developed. This reaction is characterized by its mild conditions, operational simplicity, readily available reagents, and excellent yields. A tentative mechanism for Cu-mediated C–H oxidative amination was proposed.

An efficient synthesis and in vitro antimicrobial screening of 2-cyanoimino-4-aryl-6-(1,1′-biphenyl-4-yl)-3, 4-dihydro-1H-pyrimidines

An efficient synthesis of 2-Cyanoimino-4-aryl-6-(1,1′-biphenyl-4-yl)-3,4-dihydro-1H-pyrimidines from stryl-4-biphenylketones and cyanoguanidine in presence of sodium hydroxide has been described. Cyanoguanidine serves as N-C=N source for the construction of desired cyanoiminopyrimidines. The structural assignments of the titled products were done accordingly to their spectra like Mass, FT-IR, Proton and Carbon-13NMR spectroscopy. The more stable tautomeric form was ascertained using computational frequency analysis. The tested microorganism profile of compounds exhibits significant antimicrobial activity.

Transition-Metal-Free Highly Chemoselective and Stereoselective Reduction with Se/DMF/H2O System

A novel metal-free reduction system, in which H2Se (or HSe-) produced in situ from Se/DMF/H2O acts as the active reducing species, has been developed. By using water as an inexpensive, safe, and environmentally friendly surrogate as the hydrogen donor, this new reduction system incorporating Se/DMF/H2O displayed high selectivity and good activity in the reduction of α,β-unsaturated ketones and alkynes. Therefore, this reduction system has great potential to be a general and practical reduction methodology in organic transformation.

Imidazole-triazine type compound and preparation method and application thereof

The invention provides an imidazole-triazine type compound which is shown as the formula 3 in the description and a preparation method and application thereof. The method comprises the steps that a triazine compound and an alpha,beta-unsaturated ketone type compound are mixed and added into a solvent, under the existence of a metal copper catalyst and an oxidizing material, the mixed solution is stirred and reacts 5-20 hours under the temperature of 60-150 DEG C, after the reaction is finished, the reacted solution is subjected to post processing, and the imidazole-triazine type compound which is shown as the formula 3 is obtained; the metal copper catalyst is halogenide of the copper or a copper salt; the oxidizing material is a halogen elementary substance. The imidazole-triazine type compound can be applied to prepare antibacterial drugs or antibacterial agents, and the preferred antibacterial drugs are the drugs which inhibit activity of escherichia coli.

A 2 - (4 - bromophenyl) -4 - biphenyl -6 - phenyl pyrimidine synthesis method (by machine translation)

The invention belongs to the technical field of organic electroluminescent material, discloses a 2 - (4 - bromophenyl) - 4 - biphenyl - 6 - phenyl pyrimidine synthesis method, the invention organic matter to bromophenylmethyl as raw materials, preparation

SAR studies of differently functionalized 4′-phenylchalcone based compounds as inhibitors of cathepsins B, H and L

Conditions related to the elevated levels of cathepsin B [3.4.22.1], cathepsin H [3.4.22.16] and cathepsin L [3.4.22.15] in various cancerous, rheumatoid arthritis and tissue degenerative disorders motivate the design, synthesis and evaluation of compound

Solvent free synthesis of different substituted pyrazoles under microwave irradiation via one pot synthesis and their biological evaluation

Pyrazoles and their derivative are widely used as pharmaceutical and agrochemical agents and consequently a large number of synthetic routes to pyrazole have been reported. Due to the property of reducing blood sugar by pyrazole, it has resulted in the sy