2453-44-3

Basic information

• Product Name: 1-[1,1'-BIPHENYL]-4-YL-3-PHENYLPROP-2-EN-1-ONE
• Synonyms: AKOS BBS-00000884;1-[1,1'-BIPHENYL]-4-YL-3-PHENYLPROP-2-EN-1-ONE
• CAS NO: 2453-44-3
• Molecular Formula: C₂₁H₁₆O
• Molecular Weight: 284.35
• Mol File: 2453-44-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 466.3°Cat760mmHg
• Flash Point: 205.5°C
• Appearance: /
• Density: 1.114g/cm³
• Vapor Pressure: 7.17E-09mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 1-[1,1'-BIPHENYL]-4-YL-3-PHENYLPROP-2-EN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[1,1'-BIPHENYL]-4-YL-3-PHENYLPROP-2-EN-1-ONE(2453-44-3)
• EPA Substance Registry System: 1-[1,1'-BIPHENYL]-4-YL-3-PHENYLPROP-2-EN-1-ONE(2453-44-3)

Safety Data

• Hazardous Substances Data: 2453-44-3(Hazardous Substances Data)

Usage

Class

Chalcone class of organic compounds

Physical State

Yellow solid

Usage

Commonly used in the synthesis of various natural and synthetic compounds with potential pharmacological properties

Biological Activities

a. Antioxidant
b. Anti-inflammatory
c. Anticancer
d. Antiviral
e. Antimicrobial

Potential Applications

Studied for their potential use as drug candidates for the treatment of various diseases

Fields of Interest

Chemistry, biochemistry, and pharmaceutical sciences

InChI:InChI=1/C21H16O/c22-21(16-11-17-7-3-1-4-8-17)20-14-12-19(13-15-20)18-9-5-2-6-10-18/h1-16H/b16-11+

Upstream product

• 92-91-1 biphenyl-4-acetaldehyde 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 3218-36-8 4-Phenylbenzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 98-80-6 phenylboronic acid 
• 100-42-5 styrene 
• 19710-56-6 hydroxycarbene 
• 5122-94-1 4-biphenylboronic acid 
• 92-52-4 biphenyl 

Downstream Products

• 97157-03-4 1-biphenyl-4-yl-3-(2-morpholin-4-yl-ethylsulfanyl)-3-phenyl-propan-1-one 
• 96175-26-7 1-biphenyl-4-yl-4-nitro-3,4-diphenyl-butan-1-one 
• 28621-95-6 3-(3-Biphenyl-4-yl-3-oxo-1-phenyl-propyl)-4-hydroxy-chromen-2-one 
• 30313-29-2 4-Biphenyl-4-yl-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid ethyl ester 
• 1042348-29-7 6-[1,1'-biphenyl]-4-yl-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarboxamide 
• 1400898-59-0 1-(biphenyl-4-yl)-3,5-diphenyl-1,5-pentanedione 
• 51813-17-3 3-([1,1'-biphenyl]-4-yl)-5-phenyl-1H-pyrazole 
• 2755-70-6 3-(biphenyl-4-yl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 64600-18-6 (+/-)-biphenyl-4-yl-(trans-2-phenyl-cyclopropyl)-ketone 

Relevant articles and documents

Rh(II)-Catalyzed Nitrene-Transfer [5 + 1] Cycloadditions of Aryl-Substituted Vinylcyclopropanes

Formal [5 + 1] cycloadditions between aryl-substituted vinylcyclopropanes and nitrenoid precursors are reported. The method, which employs Rh2(esp)2 as a catalyst, leads to the highly regioselective formation of substituted tetrahydropyridines. Preliminary mechanistic studies support a stepwise, polar mechanism enabled by the previously observed Lewis acidity of Rh-nitrenoids. Overall, this work expands the application of nitrene-transfer cycloaddition, a relatively underexplored approach to heterocycle synthesis, to the formation of six-membered rings.

Synthesis and characterization of 2-pyrazoline derivatives and their in silico and in vitro studies on antimicrobial and anticancer activities

The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-

An efficient synthesis and in vitro antimicrobial screening of 2-cyanoimino-4-aryl-6-(1,1′-biphenyl-4-yl)-3, 4-dihydro-1H-pyrimidines

An efficient synthesis of 2-Cyanoimino-4-aryl-6-(1,1′-biphenyl-4-yl)-3,4-dihydro-1H-pyrimidines from stryl-4-biphenylketones and cyanoguanidine in presence of sodium hydroxide has been described. Cyanoguanidine serves as N-C=N source for the construction of desired cyanoiminopyrimidines. The structural assignments of the titled products were done accordingly to their spectra like Mass, FT-IR, Proton and Carbon-13NMR spectroscopy. The more stable tautomeric form was ascertained using computational frequency analysis. The tested microorganism profile of compounds exhibits significant antimicrobial activity.