35575-96-3 Usage
Description
Azamethiphos is an organothiophosphate insecticide. It can be used as a veterinary drug used in the salmon fish farming for controlling parasites such as salmon lice (Lepeophtheirus salmonis), a marine ectoparasitic copepod on salmonid species. Its primary target is on the acetylcholinesterase, a serine hydrolase involved in neurotransmission at cholinergic synapses and neuromuscular junctions.
References
Intorre, L, et al. "Safety of azamethiphos in eel, seabass and trout." Pharmacological Research the Official Journal of the Italian Pharmacological Society 49.2(2004):171.
Kaur, K, et al. "Mechanism behind Resistance against the Organophosphate Azamethiphos in Salmon Lice (Lepeophtheirus salmonis). " Plos One 10.4(2015):e0124220.
Chemical Properties
white to light yellow crystal powde
Uses
Azamethiphos is used to control flies and other insect pests in
animal houses and also public hygiene and health pests such as mosquitoes
and cockroaches. It has recently been used to control sea lice in
salmon.
Safety Profile
Moderately toxic by ingestion andskin contact. When heated to decomposition it emits toxicvapors of NOx, SOx, POx, and Cl- .
Metabolic pathway
Azamethiphos is metabolised in mammals via hydrolysis, followed by
opening of the oxazolinone ring and conjugation of the resultant
aminopyridinol as the glucuronide and sulfate ester.
Metabolism
Azamethiphos is metabolized via the cleavage of phosphorothiolate
C?S bond, followed by N-demethylation and
opening of the oxazolinone ring and conjugation of the
resultant aminochloropyridinol as the glucuronide and
sulfate ester.
Toxicity evaluation
Acute oral LD50 for rats is 1180 mg/kg.
Inhalation LC50 (4 h) for rats is >560 mg/m3 air. ADI is
0.025 mg/kg.
Degradation
Azamethiphos is unstable in alkalis and acids. The DT50 values at pH 5,7
and 9 were 800,260 and 4.3 hours, respectively (PM).
Check Digit Verification of cas no
The CAS Registry Mumber 35575-96-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,5,7 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 35575-96:
(7*3)+(6*5)+(5*5)+(4*7)+(3*5)+(2*9)+(1*6)=143
143 % 10 = 3
So 35575-96-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H10ClN2O5PS/c1-15-18(14,16-2)19-5-12-8-7(17-9(12)13)3-6(10)4-11-8/h3-4H,5H2,1-2H3
35575-96-3Relevant articles and documents
A thiophosphate synthetic method of compound and the method in a plurality of pharmaceutical application in the synthesis of (by machine translation)
-
Paragraph 0247; 0248; 0249; 0250, (2017/07/20)
The invention discloses a having the general formula (III) of the thiophosphate synthetic method of compound, the purpose is to provide a novel, condition is simple, easy to industrial production of the thiophosphate synthetic method of compound. The method is to have the general formula (I) of the organophosphorus oxygen apperception compound having the general formula (II) with a mercaptan or phenyl-sulfhydryl apperception compound mixed, under the effects of catalyst, obtained by the reaction of the formula (III) of the thiophosphate compound. The method of the invention, can be cheap efficient synthesis of thiophosphate compounds, in actual production will have extensive application prospect. (by machine translation)
Process for the production of 2-amino-3-hydroxypyridine derivatives
-
, (2008/06/13)
2-Amino-3-hydroxy-5-chloropyridine and 2-amino-3-hydroxy-5-bromopyridine are produced by selective hydrolysis of corresponding 2-amino-3,5-dihalopyridines.
