35580-58-6

Upstream product

• 106-49-0 p-toluidine 
• 3848-42-8 O-(4-nitrophenyl)-N-(4-tolyl)carbamate 
• 4114-31-2 ethylhydrazine carboxylate 
• 622-58-2 p-Tolylisocyanate 

Downstream Products

• 79491-05-7 4-(4-methylphenyl)-1,2,4-triazolidine-3,5-dione 
• 219841-04-0 ethyl (4-tolyl)aminocarbonyldiazenecarboxylate 
• 13274-75-4 4-(4-nitrophenyl)-3H-1,2,4-triazole-3,5-dione 
• 72708-83-9 4-(4-Methylphenyl)-1,2,4-triazoline-3,5-dione 

Relevant academic research and scientific papers

One-pot and novel route for the synthesis of 4-substituted-1,2,4- triazolidine-3,5-diones

The efficient and one-pot synthesis of 4-substituted-1,2,4-triazolidin-3,5- dione derivatives (4-substituted urazoles) via combination of triphosgene, substituted anilines, and ethyl carbazate in the presence of cesium carbonate is presented.

Novel and efficient synthesis of 4-substituted-1,2,4-triazolidine-3,5- diones from anilines

A simple and efficient three-step synthetic procedure for the preparation of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles), starting from anilines, has been developed. In this method, aniline derivatives were reacted with 4-nitrophenyl chloroformate to provide corresponding carbamate derivatives. In the second step, semicarbazide derivatives were prepared from these carbamates by reaction with ethyl carbazate. The cyclization reaction of corresponding semicarbazides furnished 1,2,4-triazolidindiones in high yields. Copyright Taylor & Francis Group, LLC.