355806-92-7

Upstream product

• 33415-30-4 trichloro(propa-1,2-dienyl)silane 
• 1122-91-4 4-bromo-benzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 1216963-74-4 lithium acetylide-ethylenediamine complex 
• 148684-05-3 2-(4-bromophenyl)oxirane 
• 306282-42-8 (S)-2-(4-bromophenyl)-2-hydroxyethyl 4-methylbenzenesulfonate 
• 98475-05-9 α-tosyloxy-4-bromoacetophenone 
• 873-75-6 4-bromobenzenemethanol 
• 1402698-55-8 (R)-1-(4-bromophenyl)-4-(methyldiphenylsilyl)but-3-yn-1-ol 
• 865350-17-0 4,4,5,5-tetramethyl-2-(propa-1,2-dien-1-yl)-1,3,2-dioxaborolane 
• 106-96-7 propargyl bromide 

Relevant academic research and scientific papers

Diastereoselective Alkene Hydroesterification Enabling the Synthesis of Chiral Fused Bicyclic Lactones

Palladium-catalysed diastereoselective hydroesterification of alkenes assisted by the coordinative hydroxyl group in the substrate afforded a variety of chiral γ-butyrolactones bearing two stereocenters. Employing the carbonylation-lactonization products as the key intermediates, the route from the alkenes with single chiral center to chiral THF-fused bicyclic γ-lactones containing three stereocenters was developed.

Bi(cyclopentyl)diol-Derived Boronates in Highly Enantioselective Chiral Phosphoric Acid-Catalyzed Allylation, Propargylation, and Crotylation of Aldehydes

In this study, we disclose the catalytic addition of bi(cyclopentyl)diol-derived boronates to aldehydes promoted by chiral phosphoric acids, allowing for the formation of enantioenriched homoallylic, propargylic, and crotylic alcohols (up to >99% enantiom

Optimization of Catalyst Structure for Asymmetric Propargylation of Aldehydes with Allenyltrichlorosilane

The design of catalysts for asymmetric propargylations remains a challenging task, with only a handful of methods providing access to enantioenriched homopropargylic alcohols. In this work, guided by previously reported computational predictions, a set of

Br?nsted acid-catalyzed asymmetric allylation and propargylation of aldehydes

A method synthesizing homoallylic or homopropargylic alcohols was developed to react aldehydes with allyl boronates, such as allylboronic acid pinacol ester, or allenylborates in the presence of a catalytic amount of a chiral binaphthyl-derived chiral pho

Chiral Bronsted acid catalyzed enantioselective propargylation of aldehydes with allenylboronate

A highly enantioselective chiral Bronsted acid catalyzed propargylation of aldehydes with allenylboronate is described. The reaction is shown to be practical and quite general with a broad substrate scope covering aryl, polyaryl, heteroaryl, α,β-unsaturat

Enantioselective carbonyl propargylation by iridium-catalyzed transfer hydrogenative coupling of alcohols and propargyl chlorides

It takes alkynes! Exposure of propargyl chlorides to primary benzylic alcohols in the presence of [Ir(cod){(R)-segphos}]OTf (cod=1,5-cyclooctadiene, segphos=5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole, Tf=trifluoromethanesulfonyl) results in hydr

Bronsted acid catalyzed asymmetric propargylation of aldehydes

Which gets activated? A versatile and highly enantioselective chiral Bronsted acid catalyzed method for the propargylation of aldehydes is described to provide a range of chiral homopropargylic alcohols. Computational studies support the belief that the c

Ligand-accelerated enantioselective propargylation of aldehydes via allenylzinc reagents

An enantioselective propargylation of aldehydes using an allenylzinc reagent generated in situ via a zinc-iodine exchange reaction is described. The enantioselectivity is controlled by addition of a catalytic amount of readily accessible and highly tunable amino alcohol ligand L13. A wide range of aldehydes can be propargylated to afford valuable and versatile homopropargyl alcohols in good to excellent yields with high levels of enantiopurity.