35588-41-1Relevant academic research and scientific papers
Discovery of a Potent Botulinum Neurotoxin A Inhibitor ZM299 with Effective Protections in Botulism Mice
Gao, Jie,He, Zhili,Hong, Zhanying,Li, Tao,Luo, Deyan,Miao, Zhenyuan,Ning, Nianzhi,Wang, Hui,Wang, Jianxin,Wu, Yuelin,Xv, Xiguo,Zhang, Wannian,Zhang, Yanming,Zhuang, Chunlin
, p. 357 - 364 (2021/12/24)
Botulinum neurotoxins serotype A (BoNT/A) is the deadliest toxins known to humans and the "Category A" agent for bioterrorism. Over the past 20 years, significant efforts have been put forth to develop effective inhibitors of BoNT/A. Unfortunately, few id
Nicotinic acid or isonicotinic acid compound and application thereof
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Paragraph 0066, (2017/08/25)
The invention discloses a nicotinic acid or isonicotinic acid compound and application thereof. The compound provided by the invention is a compound as shown in formula I or the pharmaceutically acceptable salt, ester and solvate thereof. Proved by pharmacodynamic test, the sulfydryl nicotinic acid type compound provided by the invention can inhibit the activity of botulinum toxin endoprotease in vitro, and has an obvious protection effect on mice suffering from botulinum toxin poisoning. On the basis, the compound provided by the invention can be used for preparing and/or treating drugs with botulinum toxin exposure and/or poisoning.
MERCAPTONICOTINIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF
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Paragraph 0074-0079, (2016/04/19)
The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound co
BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS
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Page/Page column 179-180, (2010/11/28)
The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The inve
