3559-26-0Relevant articles and documents
Synthetic method of diclofenac sodium (by machine translation)
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, (2019/01/08)
The invention belongs to the technical field of pharmaceutical chemical synthesis, specific non-steroidal anti-inflammatory analgesic synthetic method of diclofenac sodium. Synthetic method of this invention the reaction steps are as follows: by the phenylacetic acid nitration reaction layer which O-nitrophenyl acetate (2); by the compound (2) by hydrogenation reduction reaction O-amino acetate (3); by the compound (3) amino through amidation, to obtain 2 - (2 - benzamido-phenyl) acetate (4); by the compound (4) with thionyl chloride produce chlorinated imine intermediate, then under the action of the inorganic base with 2, 6 - dichlorophenol condensation preparation (E) - Methyl - 2 - (2 - ((2, 6 - dichloro phenoxy) (phenyl) methylene amino) phenyl) ester (5); by the compound (5) by the Chapman rearrangement reaction for preparing methyl 2 - (2 - (N- (2, 6 - Dichlorophenyl) benzoyl amino) phenyl) ester (6); by the compound (6) by hydrolysis to prepare diclofenac sodium. Benzene acetic acid methyl ester calculation, the overall yield is 67%. The method of the invention raw materials are easy, economic cost, simple operation, mild reaction conditions, the industrial production is easy. (by machine translation)
Anionic [3,3]-sigmatropic rearrangement of N-phenyl-O-acylhydroxylamines to o-aminophenylcetic acids
Endo, Yasuyuki,Hizatate, Shoji,Shudo, Koichi
, p. 2803 - 2806 (2007/10/02)
N-Phenyl-O-acylhydroxylamines rearrange under basic conditions to afford o-aminophenylacetic acids. The rearrangement can be rationalized in terms of [3,3]-sigmatropic shifts of an enolized N-phenyl-O-acylhydroxyl-amine.
