3559-26-0

Basic information

• Product Name: Benzeneacetic acid, 2-(benzoylamino)-, methyl ester
• CAS NO: 3559-26-0
• Molecular Formula: C16H15NO3
• Molecular Weight: 269.3
• Mol File: 3559-26-0.mol

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 2-(benzoylamino)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-(benzoylamino)-, methyl ester(3559-26-0)
• EPA Substance Registry System: Benzeneacetic acid, 2-(benzoylamino)-, methyl ester(3559-26-0)

Safety Data

• Hazardous Substances Data: 3559-26-0(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 19958-58-8 N-benzoyl-N-phenyl-O-(acetyl)hydroxylamine 
• 304-88-1 N-phenylbenzohydroxamic acid 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 77-78-1 dimethyl sulfate 
• 35613-44-6 2-aminophenylacetic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 30095-98-8 methyl (2-nitrophenyl)acetate 
• 101-41-7 benzeneacetic acid methyl ester 

Downstream Products

• 15307-79-6 diclofenac sodium 

Relevant articles and documents

Synthetic method of diclofenac sodium (by machine translation)

The invention belongs to the technical field of pharmaceutical chemical synthesis, specific non-steroidal anti-inflammatory analgesic synthetic method of diclofenac sodium. Synthetic method of this invention the reaction steps are as follows: by the phenylacetic acid nitration reaction layer which O-nitrophenyl acetate (2); by the compound (2) by hydrogenation reduction reaction O-amino acetate (3); by the compound (3) amino through amidation, to obtain 2 - (2 - benzamido-phenyl) acetate (4); by the compound (4) with thionyl chloride produce chlorinated imine intermediate, then under the action of the inorganic base with 2, 6 - dichlorophenol condensation preparation (E) - Methyl - 2 - (2 - ((2, 6 - dichloro phenoxy) (phenyl) methylene amino) phenyl) ester (5); by the compound (5) by the Chapman rearrangement reaction for preparing methyl 2 - (2 - (N- (2, 6 - Dichlorophenyl) benzoyl amino) phenyl) ester (6); by the compound (6) by hydrolysis to prepare diclofenac sodium. Benzene acetic acid methyl ester calculation, the overall yield is 67%. The method of the invention raw materials are easy, economic cost, simple operation, mild reaction conditions, the industrial production is easy. (by machine translation)

Intramolecular C-O/C-S bond insertion of α-diazoesters for the synthesis of 2-aryl-4H-benzo[d][1,3]oxazine and 2-aryl-4H-benzo[d][1,3]thiazine derivatives

An intramolecular C-O insertion of 2-(2-arylamidophenyl)-2-diazoacetate has been achieved using a catalytic amount of copper triflate under mild conditions to produce 2-aryl-4H-benzo[d][1,3]oxazine-4-carboxylate in good yields. In addition, 2-diazo-2-(2-a

Anionic [3,3]-sigmatropic rearrangement of N-phenyl-O-acylhydroxylamines to o-aminophenylcetic acids

N-Phenyl-O-acylhydroxylamines rearrange under basic conditions to afford o-aminophenylacetic acids. The rearrangement can be rationalized in terms of [3,3]-sigmatropic shifts of an enolized N-phenyl-O-acylhydroxyl-amine.