356086-86-7

Usage

Uses

Used in Pharmaceutical Industry:
4-P-TOLYLAMINO-BUTAN-1-OL is used as a key intermediate in the synthesis of pharmaceuticals for its ability to react and form new compounds that possess therapeutic properties. Its role in drug development is crucial, as it can contribute to the creation of new medications that address various health conditions.
Used in Dye Industry:
In the dye industry, 4-P-TOLYLAMINO-BUTAN-1-OL is utilized as an intermediate for the production of dyes. Its chemical structure allows for the creation of colorants that can be used in a variety of applications, including textiles, plastics, and printing inks, due to its reactivity and ability to form stable dye molecules.
Used in Organic Synthesis:
4-P-TOLYLAMINO-BUTAN-1-OL is used as a reagent in organic synthesis, where it participates in various chemical reactions to form a range of organic compounds. Its versatility in reacting with different substances makes it a valuable component in the synthesis of specialty chemicals and materials.
Used in Chemical Product Production:
As a component in the production of chemical products, 4-P-TOLYLAMINO-BUTAN-1-OL contributes to the manufacturing process of a diverse array of chemical goods. Its inclusion in these processes is essential for achieving desired product characteristics such as color, stability, or reactivity.
While 4-P-TOLYLAMINO-BUTAN-1-OL does not present known major health hazards, it is imperative to handle 4-P-TOLYLAMINO-BUTAN-1-OL with care, adhering to established safety guidelines to ensure the well-being of individuals and the environment.

InChI:InChI=1/C11H17NO/c1-10-4-6-11(7-5-10)12-8-2-3-9-13/h4-7,12-13H,2-3,8-9H2,1H3

Upstream product

• 412283-85-3 2-p-tolyl-3,6-dihydro-2H-[1,2]oxazine 
• 13325-10-5 4-Aminobutanol 
• 624-31-7 4-tolyl iodide 
• 106-49-0 p-toluidine 
• 109-99-9 tetrahydrofuran 
• 99-99-0 1-methyl-4-nitrobenzene 
• 6117-80-2 1,4-butenediol 

Relevant academic research and scientific papers

A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines

Reaction of primary aromatic amines with peroxidic tetrahydrofuran (THF) in the presence of hydrogen and 10% palladium on carbon catalyst results in THF ring opening to give 4-N-arylamino-1-butanols in a good yield. The reaction mechanism is believed to i

Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

Herein, we report the first example of synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst.

An efficient and atom-economical route to: N -aryl amino alcohols from primary amines

In this paper we reported a novel method for generation of N-aryl amino alcohols from N,N-disubstituted picolinamides through reduction/ring-opening reaction with NaBH4. The N,N-disubstituted picolinamides can be easily obtained from primary am

Iron-catalysed tandem isomerisation/hydrosilylation reaction of allylic alcohols with amines

An iron(0)-catalysed cascade synthesis of N-alkylated anilines from allylic or homoallylic alcohols and primary and secondary anilines under hydrosilylation conditions has been developed. Notably, a simple Fe(cod)(CO)3 complex (cod = cycloocta-

Rhodium(III)-catalyzed N-nitroso-directed C-H addition to ethyl 2-oxoacetate for cycloaddition/fragmentation synthesis of indazoles

RhIII-catalyzed N-nitroso-directed C-H addition to ethyl 2-oxoacetate allows subsequent construction of indazoles, a privileged heterocycle scaffold in synthetic chemistry, through the exploitation of reactivity between the directing group and installed group. The formal [2+2] cycloaddition/fragmentation reaction pathway identified herein, a unique reactivity pattern hitherto elusive for the N-nitroso group, emphasizes the importance of forward reactivity analysis in the development of useful C-H functionalization-based synthetic tools. The synthetic utility of the protocol is demonstrated with the synthesis of a tri-cyclic-fused ring system. The diversity of covalent linkages available for the nitroso group should enable the extension of the genre of reactivity reported herein to the synthesis of other types of heterocycles.

Formation of 4-N-arylamino-1-butanol derivatives from aromatic nitro compounds via a novel palladium-catalyzed tetrahydrofuran ring-opening reaction

4-N-Arylamino-1-butanol derivatives are produced via a palladium-catalyzed tetrahydrofuran ring-opening reaction. This reaction occurs during the reduction of aromatic nitro groups with polymethylhydrosiloxane (PMHS) and potassium fluoride in the presence of hydrogen peroxide. This represents a novel route for the synthesis of 4-N-arylamino-1-butanols.

N- versus O-arylation of aminoalcohols: Orthogonal selectivity in copper-based catalysts

Two complementary protocols for copper-catalyzed arylation of aminoalcohols were developed. Selective N-arylation was accomplished at room temperature using 2-isobutyrylcyclohexanone (a β-diketone) as supporting ligand, while selective O-arylation require