356541-85-0

Upstream product

• 356541-83-8 4,9-bis-(2-methoxy-phenyl)-benzo[f]isoindole-1,3-dione 
• 356060-89-4 1,3-bis-(2-methoxy-phenyl)-isobenzofuran 
• 356060-90-7 C₂₆H₂₁NO₅ 
• 67-56-1 methanol 

Relevant academic research and scientific papers

Efficient chromatographic resolution of a configurationally fragile atropisomeric diphenol via its N-(α)-Boc-tryptophan diesters

Racemic 4,5-bis-(2-hydroxy-phenyl)-benzo[f]isoindole-1,3-dione 2, an atropisomeric diphenol prone to thermal isomerisation, has been efficiently resolved by conversion into its N-(α)-Boc-tryptophan diesters. Easy chromatographic separation of the diastereomeric pair of diesters, followed by ester cleavage under mild conditions gave each enantiomer in good yield and high enantiomeric purity. X-ray diffraction on a single crystal of one of the diastereomeric diesters allowed attribution of the absolute configuration of the stereogenic axes.

Solid-state isomerization of atropodiastereomers: Effective diastereoselection through polymorphic transformations

Diastereomeric ratios as high as 99:1 have been obtained by the solid-state isomerization of mixtures of atropodiastereomers such as trans-1a and cis-1a, whereas their solution equilibrium gave ratios close to 50:50.