35656-93-0Relevant articles and documents
Side chain conformations of oxytoxin and vasopressin studied by NMR observation of isotopic isomers
Cowburn,Live,Fischman,Agosta
, p. 7435 - 7442 (1983)
The side chain conformations of several residues of oxytocin and left bracket 8-arginine right bracket vasopressin are compared by using measurements of the circumjacent vicinal couplings of **1H** alpha , **1**3C prime , and **1**5N prime to beta protons
Achiral deuterated derivatizing agent for enantiomeric analysis of carboxylic acids by NMR in a chiral liquid crystalline solvent
Meddour, Abdelkrim,Courtieu, Jacques
, p. 3635 - 3644 (2000)
The use of a deuterated 'probe' for the enantiomeric analysis of chiral carboxylic acids is proposed. The probe is the perdeuterobenzyl fragment which can be easily attached to the acid and removed from the corresponding ester. The analysis is performed t
Effect of sequence distribution on copolymer interfacial activity
Lefebvre, Michelle D.,Dettmer, Christine M.,McSwain, Rachel L.,Xu, Chen,Davila, Jonathan R.,Composto, Russell J.,Nguyen, SonBinh T.,Shull, Kenneth R.
, p. 10494 - 10502 (2005)
Interfacial segregation of diblock, gradient, and random copolymers was measured using forward recoil spectrometry. The polymers were synthesized by a ring-opening metathesis polymerization, allowing a high degree of control over the sequence distribution
Palladium-Catalyzed Regioselective C-H Alkenylation of Arylacetamides via Distal Weakly Coordinating Primary Amides as Directing Groups
Jaiswal, Yogesh,Kumar, Yogesh,Kumar, Amit
, p. 1223 - 1231 (2018)
Herein we disclose the efficient Pd(II)-catalyzed and regioselective ortho C-H alkenylation of arylacetamide derivatives, viz. weakly coordinating aliphatic primary amides. This protocol utilizes ubiquitous free primary amides as the directing group and c
Deuterated compound based on cavity enterostatin - h as well as preparation method and application thereof
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Paragraph 0028; 0066-0068, (2021/11/26)
The invention discloses a deuterated compound based on caescein - h, a preparation method and application thereof, and the chemical structural formula is as follows. In-flight R1 Phenyl or deuterated phenyl groups R2 Hydrogen or deuterium, R3 Hydrogen or deuterium, R4 Hydrogen or deuterium, R5 Hydrogen or deuterium, R6 Hydrogen or deuterium, R1 -R6 At least one group in the group is a deuterated group. The deuterated compound provided by the invention is used as a biological luminescent substrate, and can monitor the distribution of luciferase in vivo and outside. Compared with the cavity enterostatin - h, the method for preparing the deuterated compound of the cavity enterostatin - is simple, the reaction steps are classic, the operability is high, the cost - h is low, and the method has a good practical value.
Imidazopyrazinone compound as well as preparation method and application thereof
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Paragraph 0070; 0114-0116, (2021/10/11)
The invention provides an imidazopyrazinone compound as well as a preparation method and application thereof. The imidazopyrazinone compound structure has the structure shown I, and R. 1 Is phenyl. R2 In the benzyl group, and the compound has at least one D substituent, the D substituent is at R. 1 And/or R2 . The compound has excellent luminescence performance, can be used as a substrate of NanoLuc luminescent system, and is applied to detection and drug detection of luciferase.
A carboxylate-assisted amination/unactivated C(sp2)-H arylation reactionviaa palladium/norbornene cooperative catalysis
An, Yang,Zhang, Bo-Sheng,Zhang, Zhe,Liu, Ce,Gou, Xue-Ya,Ding, Ya-Nan,Liang, Yong-Min
supporting information, p. 5933 - 5936 (2020/06/04)
This report describes a carboxylate-assisted palladium-catalysed Catellani reaction, which is compatible withortho-amination and unactivated C(sp2)-H arylation. This method was used to synthesize a series of 1-amino substituted dihydrophenanthridines, phenanthridines and 6H-benzo[c]chromenes. Based on kinetic isotope experiments, the kinetic curve proves that pivalic acid accelerates the reaction rate of unactivated C(sp2)-H activation, and thus this rate can keep up with the five membered aryl-norbornene-palladacycle (ANP) intermediate.
Co(III)-Catalyzed [4+1] Annulation of Amides with Allenes via C?H Activation
Boobalan, Ramadoss,Santhoshkumar, Rajagopal,Cheng, Chien-Hong
supporting information, p. 1140 - 1145 (2019/01/30)
A Co(III)-catalyzed [4+1] annulation of amides with allenes to synthesize isoindolone and 1,5-dihydro-pyrrol-2-one derivatives is reported. A wide range of aromatic and vinylic amides react with allenes to give the corresponding annulation products in good to excellent yields. The mechanistic studies strongly support that the catalytic reaction proceeds through an amide-directed C?H activation, followed by carbocobaltation of allene, β-hydride elimination, and an intramolecular 1,2-hydroamination. (Figure presented.).
Synthesis of dibenzo[c,e]oxepin-5(7H)-ones from benzyl thioethers and carboxylic acids: Rhodium-catalyzed double C-H activation controlled by different directing groups
Zhang, Xi-Sha,Zhang, Yun-Fei,Li, Zhao-Wei,Luo, Fei-Xian,Shi, Zhang-Jie
supporting information, p. 5478 - 5482 (2015/04/27)
A rhodium(III)-catalyzed cross-coupling of benzyl thioethers and aryl carboxylic acids through the two directing groups is reported. Useful structures with diverse substituents were efficiently synthesized in one step with the cleavage of four bonds (C-H, C-S, O-H) and the formation of two bonds (C-C, C-O). The formed structure is the privileged core in natural products and bioactive molecules. This work highlights the power of using two different directing groups to enhance the selectivity of a double C-H activation, the first of such examples in cross-oxidative coupling.
The synthesis and structures of deuterium-labeled 5-substituted 1H-tetrazoles
Zhao, Hong
, p. 293 - 296 (2008/12/22)
The synthesis and crystal structures of deuterium-labeled 5-substituted 1H-tetrazoles, 5-[2H5]phenyl-1H-tetrazole (I), 5-[ 2H7]tolyl-1H-tetrazole (II), and 5-[2H 7]benzyl-1H-tetrazole (III)
