35657-40-0

Basic information

• Product Name: tert-butyl [(2,2-dimethylpropanoyl)oxy]carbamate
• CAS NO: 35657-40-0
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.2622
• Mol File: 35657-40-0.mol
• Article Data: 14

Chemical Properties

• Density: 1.037g/cm³
• Refractive Index: 1.442
• CAS DataBase Reference: tert-butyl [(2,2-dimethylpropanoyl)oxy]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [(2,2-dimethylpropanoyl)oxy]carbamate(35657-40-0)
• EPA Substance Registry System: tert-butyl [(2,2-dimethylpropanoyl)oxy]carbamate(35657-40-0)

Safety Data

• Hazardous Substances Data: 35657-40-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl [(2,2-dimethylpropanoyl)oxy]carbamate, also known as BOC-protected alanine, is a chemical compound commonly used in organic synthesis. It is a derivative of alanine, an amino acid that is essential for protein synthesis in the body. The tert-butyl group at one end of the molecule provides stability and protection for the amino acid moiety, making it easier to manipulate in chemical reactions. The (2,2-dimethylpropanoyl)oxy group serves as a protecting group for the carbamate functionality, preventing unwanted reactions at this site during synthetic processes. Overall, tert-butyl [(2,2-dimethylpropanoyl)oxy]carbamate is a valuable tool in the field of organic chemistry for the synthesis of complex molecules and peptides.

Upstream product

• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 75-98-9 Trimethylacetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 33957-35-6 2-phenyl-pyrido<1,2-a>-1,3,5-triazin-4-one 
• 1318768-17-0 N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline 

Relevant articles and documents

COMPOSITIONS FOR MODULATING SPLICING

Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Regioselective Radical Arene Amination for the Concise Synthesis ofortho-Phenylenediamines

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactiveN-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the areneorthoposition. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly toortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsymmetrical, selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuableortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

A catalyst-free method for the synthesis of 1,4,2-dithiazoles from isothiocyanates and hydroxylamine triflic acid salts

A catalyst-free method for the preparation of 1,4,2-dithiazoles is developed by reactions of isothiocyanates with hydroxylamine triflic acid salts. This reaction achieves C-S, C-N, and S-N bond formation, and a range of products are obtained in moderate to good yields. The obvious feature is using shelf-stable hydroxylamine triflic acid salts as a N source to synthesize heterocycles under mild conditions.