33957-35-6

Upstream product

• 590-28-3 potassium cyanate 
• 107264-09-5 1-fluoro-pyridinium tetrafluoroborate 
• 100-47-0 benzonitrile 
• 100-52-7 benzaldehyde 
• 504-29-0 2-aminopyridine 
• 1883-96-1 (phenylmeth-(E)-ylidene)pyridin-2-yl-amine 
• 1415486-61-1 ethyl (pivaloyloxy)carbamate 
• 35657-40-0 tert-butyl (pivaloyloxy)carbamate 
• 16844-21-6 N-Chlorourethan 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 4931-08-2 N-(pyridin-2-yl)benzimidamide 
• 124-38-9 carbon dioxide 

Relevant academic research and scientific papers

A Novel Synthesis of 2-Substituted Pyrido-1,3,5-triazin-4-ones by the Reaction of N-Fluoropyridinium Salts with Cyanate Ion and Carbonitriles: Evidence in Support of a Carbene Intermediate

A carbene 5" derived from N-fluoropyridinium cation is the suggested intermediate in the novel synthesis of pyridotriazines 3.

Rh(III)-Catalyzed imidoyl C-H carbamylation and cyclization to bicyclic [1,3,5]triazinones

A Rh(III)-catalyzed synthesis of bicyclic [1,3,5]-triazinones from a diverse array of imines coupled with ethyl (pivaloyloxy)carbamate is reported. The preparation of [5,6]- and [6,6]-bicyclic heterocycles substituted with aryl, alkyl, and alkoxy groups demonstrated a broad reaction scope. The efficiency of this approach was further enhanced with the development of a three-component variant featuring in situ imine formation. X-ray crystallographic characterization of a rhodacycle formed by imidoyl C-H activation provides support for the proposed mechanism.

Oxidant-Mediated Nitrogenation and Recyclization of Imidazo[1,2-a]pyridines with Sodium Azide: Synthesis of 4H-Pyrido[1,2-a][1,3,5]triazin-4-ones

An expeditious and straightforward approach for the synthesis of 4H-pyrido[1,2-a][1,3,5]triazin-4-ones starting from readily available imidazo[1,2-a]pyridines and sodium azide has been presented under aerobic oxidative conditions. The reaction proceeded well with the promotion of potassium persulfate/potassium permanganate with good functional group tolerance. A wide range of biologically valuable 4H-pyrido[1,2-a][1,3,5]triazin-4-one scaffolds were assembled by this methodology. The gram-scale reaction was also achieved. A cascade nitrogenation and oxidative recyclization sequence could be involved in the reaction. (Figure presented.).

The dearomative annulation between N -2-pyridylamidine and CO2 toward pyrido[1,2-a]-1,3,5-triazin-4-ones

A base-promoted dearomative annulation between N-2-pyridylamidine and an atmospheric pressure of CO2 was developed, affording a series of pyrido[1,2-a]-1,3,5-triazin-4-ones in moderate to excellent yields. CO2 served as a carbonyl so