35661-50-8

Basic information

• Product Name: Carbamic acid, cyclohexyl-, 9H-fluoren-9-ylmethyl ester
• CAS NO: 35661-50-8
• Molecular Formula: C21H23NO2
• Molecular Weight: 321.419
• Mol File: 35661-50-8.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, cyclohexyl-, 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, cyclohexyl-, 9H-fluoren-9-ylmethyl ester(35661-50-8)
• EPA Substance Registry System: Carbamic acid, cyclohexyl-, 9H-fluoren-9-ylmethyl ester(35661-50-8)

Safety Data

• Hazardous Substances Data: 35661-50-8(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 84418-43-9 9-fluorenylmethyl carbamate 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 909114-66-5 9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate 
• 108-91-8 cyclohexylamine 
• 511244-41-0 N-(9-fluorenylmethoxycarbonyl)-5,7-dinitroindoline 

Relevant articles and documents

Photo-on-Demand Synthesis of Chloroformates with a Chloroform Solution Containing an Alcohol and Its One-Pot Conversion to Carbonates and Carbamates

Chloroformates are key reagents for synthesizing carbonates and carbamates. The present study reports a novel photo-on-demand in situ synthesis of chloroformates with a CHCl3 solution containing a primary alkyl alcohol. It further allowed the one-pot synthesis of carbonates and carbamates through subsequent addition of alcohols or amines, respectively.

A greener, efficient and catalyst-free ultrasonic-assisted protocol for the n-fmoc protection of amines

A simple, eco-sustainable method for the N-(9-fluorenylmethoxycarbonyl) (N-Fmoc) protection of various structurally amines under ultrasonic irradiation is reported. The corresponding N-Fmoc derivatives were obtained in good to excellent yields within short reaction time. The reaction proceeds without the formation of any side product. Mildness, efficiency and easier work are the main advantages of this new protocol.

Stereoselective direct reductive amination of ketones with electron-deficient amines using Re2O7/NaPF6 catalyst

The first example of direct reductive amination (DRA) of ketones with electron-deficient amines (EDA) such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, etc. protected amines have been achieved using catalytic Re2O7/NaPF6. Excellent chemoselectivities as well as diastereoselectivity (for 2-alkyl cyclohexanones) were obtained. The Royal Society of Chemistry 2013.

An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media

A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles.

Useful reagents for introduction of Boc and Fmoc protective groups to amines: Boc-DMT and Fmoc-DMT

New amino-protecting reagents, Boc-DMT and Fmoc-DMT, were prepared, and found to be useful for the introduction of Boc and Fmoc groups into amines. Both the reagents can protect various amines including amino acids in good yield in aqueous media. Since the reagents are neither unstable nor irritating, they are practically useful. Georg Thieme Verlag Stuttgart.

Photochemical protection of amines with Cbz and Fmoc groups

The photochemical conversion of amines into carbamates was achieved using N-Cbz-, N-Fmoc-, and N-Boc-5,7-dinitroindolines. This reaction allows the protection of amines in neutral medium. Primary and unhindered secondary amines were protected to yield their benzyloxycarbonyl- and 9-fluorenylmethoxycarbonyl derivatives efficiently, whereas bulky amines or anilines gave low yields or no product. On the other hand, the formation of N-Boc compounds, although possible, proceeded only with low yields.