35667-35-7

Upstream product

• 78362-94-4 {PPN}{HCr(CO)5} 
• 1455-13-6 deuteromethanol 
• 638-29-9 n-valeryl chloride 
• 109-72-8 n-butyllithium 
• 2914-27-4 d1-N,N-dimethylformamide 

Downstream Products

• 1393604-72-2 (1S)-1-(p-tolylsulfonyloxy)-[1-⁽²⁾H₁]pentane 
• 1393604-75-5 (4R)-1-(p-tolylsulfonyloxy)-[4-⁽²⁾H₁]-oct-2-yne 
• 1393604-62-0 (1R)-1-(p-tolylsulfonyloxy)-[1-⁽²⁾H₁]pentane 
• 1393604-68-6 (4S)-1-(p-tolylsulfonyloxy)-[4-⁽²⁾H₁]-oct-2-yne 

Relevant academic research and scientific papers

Topological study of mechanistic diversity in conjugated fatty acid biosynthesis

Variations on an oxidative theme: The precision with which FAD2-type desaturases carry out C-H activation reactions on flexible lipidic substrates is astonishing. The conformational space available within the active site of these enzymes has been explored using deuterium-labeled substrates, and evidence for a novel quasi-eclipsed conformer has been uncovered. The scheme shows some prototypical substrate conformations. Copyright

Selective reduction of acyl chlorides to aldehydes by anionic 6B transition-metal hydrides

Acyl chlorides can be selectively and rapidly reduced, under mild conditions, by group 6B anionic hydrides, HM(CO)4L- (M = Cr, W; L = CO, PR3), giving the corresponding aldehydes and the metal chlorides CIM(CO)4L-. The reaction is nearly quantitative for both aliphatic and aromatic acyl chlorides using solvent systems such as dichloromethane, tetrahydrofuran, or acetonitrile. Only in the presence of acid will the aldehydes consume a second equivalent of hydride, subsequently being reduced to alcohols. The anionic hydrides selectively reduce acyl chlorides in the presence of other reducible groups such as alkyl bromides or nitro aromatics. In situ preexchange of hydrogen by deuterium (HM(CO)4L-/ CH3OD → DM(CO)4L-/CH3OH) allows for deuterium delivery, giving RCDO products, as indicated by 2H NMR.