356758-00-4

Upstream product

• 65-85-0 benzoic acid 
• 90321-71-4 3-(2-furyl)acrylic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 443978-46-9 N'-benzoyl-N-[3-(2-furyl)acrylo]hydrazine 
• 117071-05-3 K⁽¹⁺⁾*OOCCHCHC₄H₃O^(1-)=KOOCCHCHC₄H₃O 
• 1663-61-2 triethoxymethylbenzene 

Relevant academic research and scientific papers

An efficient synthesis of conjugated 5-aryl-1,3,4-oxadiazoles from 3-heteroarylacrylohydrazides and acid chlorides

New derivatives of 5-aryl-2-[2-(2-furyl)ethenyl]-1,3,4-oxadiazoles and 5-aryl-2-[2-(2-thienyl)ethenyl]-1,3,4-oxadiazoles are synthesized in a stepwise procedure through intermediate acyclic N′-arylcarbonyl-N-[2-(2-heteroaryl) acryloyl]hydrazines, starting from 3-(2-heteroaryl)acrylic acid hydrazides and acid chlorides. A facile one-pot methodology leading to the final 1,3,4-oxadiazoles is also described.

Efficient synthesis of 1,3,4-oxadiazoles conjugated to thiophene or furan rings via an ethenyl linker

A novel and efficient synthesis of 5-substituted 2-[2-(2-furyl)ethenyl]-1, 3,4-oxadiazoles and 2-[2-(2-thienyl)ethenyl]-1,3,4-oxadiazoles by cyclocondensation of the appropriate 3-(2-furyl)- and 3-(2-thienyl) acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid is reported. The formation of symmetrically substituted 2,5-bis[2-(2-furyl)ethenyl]-1,3,4-oxadiazole and 2,5-bis[2-(2-thienyl)ethenyl]- 1,3,4-oxadiazole from the corresponding N,N′-diacylhydrazines under the influence of phosphorus oxychloride is also described. Georg Thieme Verlag Stuttgart. New York.