603-69-0

Basic information

• Product Name: Ethyl diacetoacetate
• Synonyms: Acetoacetic acid, 2-acetyl-, ethyl ester;Butanoic acid, 2-acetyl-3-oxo-, ethyl ester;Ethyl 2-acetyl-3-oxobutanoate;Ethyl 2-acetylacetoacetate;DIACETOACETIC ACID ETHYL ESTER;ETHYL 2-ACETYL-3-OXOBUTYRATE;ETHYL DIACETOACETATE;ETHYL DIACETYL ACETATE
• CAS NO: 603-69-0
• Molecular Formula: C₈H₁₂O₄
• Molecular Weight: 172.18
• EINECS: 210-053-3
• Product Categories: Pharmaceutical Intermediates;Acetics acid and esters;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 603-69-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 104-105 °C17 mm Hg(lit.)
• Flash Point: 185 °F
• Appearance: clear colorless to yellow liquid
• Density: 1.104 g/mL at 25 °C(lit.)
• Vapor Pressure: 8.24E-06mmHg at 25°C
• Refractive Index: n20/D 1.47(lit.)
• PKA: 6.93±0.46(Predicted)
• Water Solubility: Not miscible in water.
• BRN: 775014
• CAS DataBase Reference: Ethyl diacetoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl diacetoacetate(603-69-0)
• EPA Substance Registry System: Ethyl diacetoacetate(603-69-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• Hazardous Substances Data: 603-69-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

Ethyl diacetoacetate is used in the preparation of 3-acetyl-6-chloro-7-hydroxy-4-methylcoumarin. It is used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

General Description

Ethyl diacetoacetate reacts with o-phenylenediamine to yield 2-methylbenzimidazole perchlorate.

InChI:InChI=1/C8H12O4/c1-4-12-8(11)7(5(2)9)6(3)10/h11H,4H2,1-3H3

Upstream product

• 29214-62-8 3-acetoxy-crotonic acid ethyl ester 
• 108-24-7 acetic anhydride 
• 141-97-9 ethyl acetoacetate 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 75-36-5 acetyl chloride 
• 71-43-2 benzene 
• 16486-97-8 1-Chloro-1,1,2,2,3,3,4,4,5,5,6,6-dodecafluoro-6-iodo-hexane 
• 7664-93-9 sulfuric acid 
• 67-66-3 chloroform 
• 15435-71-9 sodium acetylacetonate 
• 541-41-3 chloroformic acid ethyl ester 
• 60-29-7 diethyl ether 
• 141-78-6 ethyl acetate 
• 7637-07-2 boron trifluoride 

Downstream Products

• 89193-18-0 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 64-19-7 acetic acid 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 346441-17-6 1-(3-fluorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 346441-16-5 3,5-dimethyl-1-m-tolyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 103409-93-4 ethyl 1-(4-tolyl)-3,5-dimethylpyrazole-4-carboxylate 
• 346441-13-2 1-Benzyl-3,5-dimethyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester 
• 2436-79-5 diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate 
• 75163-04-1 N-benzoyl-O-(1-carbethoxy-1-acetylisopropenyl)urethan 
• 91614-62-9 2-acetyl-3-methyl-7-phenylpyrazolo<1,2-a>pyrazole-1,5(1H,5H)-dione 
• 91614-67-4 2-acetyl-3-methyl-5-phenylpyrazolo<1,2-a>pyrazole-1,7(1H,7H)-dione 
• 113858-93-8 3-cyano-4,6-dimethyl-5-(ethoxycarbonyl)pyridine-2(1H)-thione 
• 119-61-9 benzophenone 

Relevant articles and documents

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Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1