35692-20-7

Upstream product

• 681-84-5 tetramethylorthosilicate 

Downstream Products

• 1186241-74-6 N-(3-m-tolyl-2H-chromen-4-yl)acetamide 
• 1205-64-7 3-Methyldiphenylamine 
• 82942-79-8 3'-methyl-5,6-dihydro[1,1'-biphenyl]-3(4H)-one 
• 7383-90-6 3,4'-dimethylbiphenyl 
• 23099-05-0 3-methyl-N-phenylbenzamide 
• 1235271-47-2 4-(3-methyl-benzyl)-benzonitrile 
• 1608124-59-9 1-(pyrimidin-2-yl)-2-(m-tolyl)-1H-indole 
• 1335209-92-1 2-(3'-methyl-5-methoxybiphenyl-2-yl)pyridine 
• 1215003-88-5 2-(3'-methyl-[1,1'-biphenyl]-2-yl)pyridine 
• 70603-13-3 1,2-diphenyl-1-m-tolyl-ethene 
• 85462-13-1 1-m-tolyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecan-3-one 

Relevant academic research and scientific papers

Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis

We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.

Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes

We describe herein a regioselective palladium(II)catalyzed intermolecular hydroarylation of unactivated aliphatic alkenes with electronically and sterically diverse (hetero)arylsilanes under redox-neutral conditions. A removable bidentate 8-amino-quinoline auxiliary was readily employed to dictate the regioselectivity, prevent β-hydride elimination, and facilitate protodepalladation. This silicon-based protocol features a broad substrate scope with excellent functional group compatibility and enables an expeditious route to a variety of γ-aryl butyric acid derivatives in good yields with exclusive anti-Markovnikov selectivity.