80245-34-7

Basic information

• Product Name: 4-Nitro-4'-(trifluoroMethyl)-1,1'-biphenyl
• Synonyms: 4-Nitro-4'-(trifluoroMethyl)-1,1'-biphenyl;1-Nitro-4-[4-(trifluoroMethyl)phenyl]benzene
• CAS NO: 80245-34-7
• Molecular Formula: C₁₃H₈F₃NO₂
• Molecular Weight: 267.2033296
• Mol File: 80245-34-7.mol
• Article Data: 34

Chemical Properties

• Melting Point: 121-122 °C
• Boiling Point: 331.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Nitro-4'-(trifluoroMethyl)-1,1'-biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-4'-(trifluoroMethyl)-1,1'-biphenyl(80245-34-7)
• EPA Substance Registry System: 4-Nitro-4'-(trifluoroMethyl)-1,1'-biphenyl(80245-34-7)

Safety Data

• Hazardous Substances Data: 80245-34-7(Hazardous Substances Data)

Usage

General Description

4-Nitro-4'-(trifluoromethyl)-1,1'-biphenyl, also known as NTB, is a chemical compound consisting of a biphenyl backbone with a nitro group at the 4-position and a trifluoromethyl group at the 4'-position. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. NTB is also used as a reagent in organic chemistry reactions and as a precursor in the manufacture of dyes and pigments. The trifluoromethyl group in NTB makes it a valuable reagent for introducing CF3 groups into organic molecules, and its nitro group can be easily converted into other functional groups, making NTB a versatile and valuable chemical reagent in organic synthesis. However, it is important to handle NTB with caution as it is considered to be harmful if ingested, inhaled, or in contact with skin.

Upstream product

• 398-36-7 1-phenyl-4-(trifluoromethyl)benzene 
• 540-80-7 tert.-butylnitrite 
• 109-63-7 boron trifluoride diethyl etherate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 100-01-6 4-nitro-aniline 
• 586-78-7 para-nitrophenyl bromide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 52323-94-1 trimethyl(4-nitrophenyl)stannane 
• 100-00-5 4-chlorobenzonitrile 
• 35692-32-1 trimethoxy(4-(trifluoromethyl)phenyl)silane 
• 636-98-6 p-nitrobenzene iodide 
• 56-23-5 tetrachloromethane 
• 92-93-3 1-phenyl-4-nitrobenzene 

Downstream Products

• 57688-34-3 4'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine 
• 92-89-7 4'-nitro-biphenyl-4-carboxylic acid 

Relevant articles and documents

Biaryl Coupling of Aryldiazonium Salts and Arylboronic Acids Catalysed by Gold

A gold-catalysed coupling of aryldiazonium salts with arylboronic acids is described. The reactions proceed in satisfactory yields under irradiation with blue LEDs in the presence of KF and a catalytic amount of ascorbic acid. Notably, 4-nitrobenzendiazonium tetrafluoroborate is sufficiently reactive to undergo the coupling with a variety of arylboronic acids in the absence of aryl radical initiators. The coupling is applicable for electron-donating and electron-withdrawing groups present at the para, ortho, and meta positions of both substrates.

An efficient clean and sustainable methodology for catalytic C-C coupling process over a Pd-free magnetically recoverable cobalt catalyst

The Suzuki and Sonogashira coupling reactions are important processes in organic synthesis. However, to date, these reactions have been extensively examined using Pd-based catalysts in toxic organic solvents. Therefore, developing clean and inexpensive methodologies for these reactions remained a major challenge. Herein, by taking the advantages of thiol-ene click reaction, an easy and robust strategy for surface modification of magnetic graphene oxide with a dendrimer structure was successfully developed. Dendrimer-functionalized magnetic graphene oxide was then applied for the immobilization of Co nanoparticles. Transmission electron microscopy exhibited a homogeneous distribution of Co nanoparticles with the size of about 3 nm. The resultant nanocomposite revealed high efficiency in catalytic Suzuki and Sonogashira reactions in non-hazardous and sustainable deep eutectic solvents (DESs). The DES and catalyst were simply recycled five times with gradual slight decrease in the yield of the reactions. More importantly, the catalyst was magnetically isolated at the end of the recycling process. Overall, the utilization of DES as an environmentally friendly and recoverable reaction medium, as well as replacing the low-cost cobalt catalyst as an alternative to expensive Pd catalyst along with the facile catalyst isolation by employing an external magnetic field, make the present protocol promising from economic and green chemistry points of view for the clean C-C coupling reactions.

Green and sustainable palladium nanomagnetic catalyst stabilized by glucosamine-functionalized Fe3O4@SiO2 nanoparticles for Suzuki and Heck reactions

A novel magnetic and heterogeneous palladium-based catalyst stabilized by glucosamine-functionalized magnetic Fe3O4@SiO2 nanoparticle was synthesized. The strategy relies on the covalently bonding of glucosamine to cyanuric chloride-functionalized magnetic nanoparticles followed by complexation with palladium. The structure of magnetic nanocatalyst was fully determined by FT-IR, XRD, DLS, FE-SEM, TEM, ICP, UV-Vis, TGA, VSM, and EDX. The obtained results confirmed that the palladium nanoparticles stabilized by glucosamine immobilized onto the magnetic support exhibited high activity in cross-coupling reactions of Suzuki-Miyaura and Mizoroki-Heck. Various aryl halides were coupled with arylboronic acid (Suzuki cross-coupling reaction) and olefins (Heck reactions) under the green conditions to provide corresponding products in high to excellent yields. Interestingly, the catalyst can be easily isolated from the reaction media by magnetic decantation and can subsequently be applied for consecutive reaction cycles (at least seven times) with no notable reduction in the catalytic activity.