357-83-5

Basic information

• Product Name: (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE
• Synonyms: N,N-DIETHYL(2-CHLORO-1,1,2-TRIFLUOROETHYL)AMINE;YAROVENKO'S REAGENT;(2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE;2-Chloro-1,1,2-trifluorotriethylamine;DIETHYL-(2-CHLORO-1,1,2-TRIFLUORO-ETHYL)-AMINE;(2-Chloro-1,1,2-trifluoroethyl)-N,N-diethylamine~Yarovenkos;(2-Chloro-1,1,2-trifluoroethyl)-N,N-diethylamine~Yarovenko'sReagent;(2-Chloro-1,1,2-trifluoroethyl)diethylamine(Yarovenko'sreagent)
• CAS NO: 357-83-5
• Molecular Formula: C₆H₁₁ClF₃N
• Molecular Weight: 189.61
• EINECS: -0
• Mol File: 357-83-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 38 °C
• Flash Point: 38°C/10mm
• Appearance: Clear brown liquid
• Density: 1,19 g/cm3
• Vapor Pressure: 24.4mmHg at 25°C
• Refractive Index: n20/D1.396
• Storage Temp.: 2-8°C
• PKA: 1.30±0.70(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 1098675
• CAS DataBase Reference: (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE(357-83-5)
• EPA Substance Registry System: (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE(357-83-5)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38-34-10
• Safety Statements: 26-36/37/39-45
• RIDADR: 3267
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 357-83-5(Hazardous Substances Data)

Usage

Chemical Properties

Clear brown liquid

InChI:InChI=1/C6H11ClF3N/c1-3-11(4-2)6(9,10)5(7)8/h5H,3-4H2,1-2H3

Upstream product

• 354-51-8 1,2-dibromo-1-chloro-1,2,2-trifluoroethane 
• 109-89-7 diethylamine 
• 75988-27-1 adduct of (1,1,2-trifluoro-2-chloroethyl)diethylamine with trimethylsilyl isocyanate (1:2) 
• 79-38-9 Chlorotrifluoroethylene 

Downstream Products

• 557-99-3 acetyl fluoride 
• 655-23-2 chloro-fluoro-thioacetic acid diethylamide 
• 430-71-7 propionyl fluoride 
• 461-53-0 butanoyl fluoride 
• 15981-92-7 2,3'-anhydrothymidine 
• 359-70-6 perfluorotriethylamine 
• 63419-65-8 (2-Chloro-1,1,2,2-tetrafluoro-ethyl)-pentafluoroethyl-trifluoromethyl-amine 
• 60940-97-8 Perfluor-2-chlor-N,N-diethyl-ethylamin 
• 63419-66-9 Perfluor-2,2'-dichlor-triethylamin 
• 2366-52-1 1-fluorobutane 
• 364-94-3 N,N-diethylchlorofluoroacetamide 

Relevant articles and documents

Method for preparing fluorinating reagent and fluoride continuously by microchannel reactor

The invention discloses a method for preparing a fluorinating reagent and fluoride continuously by a microchannel reactor. The method comprises the following steps: introducing a mixed solution of amine and a solvent as well as fluorine-containing olefin into the microchannel reactor separately, performing reaction at the reaction temperature of subzero 20 to 30 DEG C for 30 to 180 seconds to prepare the fluorinating reagent, introducing the fluorinating reagent and a compound A into the microchannel reactor, performing mixing, heating and reaction to obtain a compound B, and performing hydrolysis reaction on the reaction liquid of the compound B to obtain a compound C. The method is simple to operate and safe to use, the use amount of the materials is greatly reduced, the process is environmentally-friendly and continuous, and the risk of high pressure and high temperature is avoided, so that high-yield continuous production of the fluorinating agent or fluoride is feasible. The comprehensive yield of the fluoride reaches 90 to 95 percent, basic quantitative reaction of the fluorinating reagent is realized and industrialized production is facilitated.

Process for the preparation of side chain-fluorinated alkyloxazoles, and new side chain-fluorinated alkyloxazoles

A process for the preparation of side chain-fluorinated alkyloxazoles, wherein hydroxyalkyloxazoles are reacted with an α,α-difluoroalkylamine at pressures of under 2 bar, in the presence of an inert solvent boiling at above 100° C. (at normal pressure), and new fluorinated alkyloxazoles.

N-PERHALOFLUOROALKYLATION OF SECONDARY AMINES BY THE REACTIONS OF THE AMINES AND AMIDES WITH PERHALOFLUOROALKANES. HALOPHILIC ATTACK OF NITROGEN NUCLEOPHILE ON C-Br BOND.

Secondary amines and amides react spontaneously with perhalofluoroalkanes CF2BrCFBrX(X = F, Cl, CF3) to afford N-perhalofluoroalkylated tertiary amines in fair to good yields.Evidence for an anionic chain process initiated by the bromophilic attack of nitrogen nucleophiles on C-Br bonds is given.