357-83-5

Usage

Chemical Properties

Clear brown liquid

InChI:InChI=1/C6H11ClF3N/c1-3-11(4-2)6(9,10)5(7)8/h5H,3-4H2,1-2H3

Upstream product

• 354-51-8 1,2-dibromo-1-chloro-1,2,2-trifluoroethane 
• 109-89-7 diethylamine 
• 75988-27-1 adduct of (1,1,2-trifluoro-2-chloroethyl)diethylamine with trimethylsilyl isocyanate (1:2) 
• 79-38-9 Chlorotrifluoroethylene 

Downstream Products

• 430-71-7 propionyl fluoride 
• 461-53-0 butanoyl fluoride 
• 2366-52-1 1-fluorobutane 
• 364-94-3 N,N-diethylchlorofluoroacetamide 
• 15981-92-7 2,3'-anhydrothymidine 
• 4074-09-3 α-hydrohexafluoroisobutyric aldehyde 
• 75988-33-9 N-2,4,6-trichlorophenyl-N'-<2-chloro-2-fluoro-1-(diethylamino)ethylidene>biuret 
• 75988-30-6 O-2,4-dichlorophenyl-N-<2-chloro-2-fluoro-1-(diethylamino)ethylidene>allophanate 
• 359-70-6 perfluorotriethylamine 

Relevant academic research and scientific papers

Method for preparing fluorinating reagent and fluoride continuously by microchannel reactor

The invention discloses a method for preparing a fluorinating reagent and fluoride continuously by a microchannel reactor. The method comprises the following steps: introducing a mixed solution of amine and a solvent as well as fluorine-containing olefin into the microchannel reactor separately, performing reaction at the reaction temperature of subzero 20 to 30 DEG C for 30 to 180 seconds to prepare the fluorinating reagent, introducing the fluorinating reagent and a compound A into the microchannel reactor, performing mixing, heating and reaction to obtain a compound B, and performing hydrolysis reaction on the reaction liquid of the compound B to obtain a compound C. The method is simple to operate and safe to use, the use amount of the materials is greatly reduced, the process is environmentally-friendly and continuous, and the risk of high pressure and high temperature is avoided, so that high-yield continuous production of the fluorinating agent or fluoride is feasible. The comprehensive yield of the fluoride reaches 90 to 95 percent, basic quantitative reaction of the fluorinating reagent is realized and industrialized production is facilitated.

Process for the preparation of side chain-fluorinated alkyloxazoles, and new side chain-fluorinated alkyloxazoles

A process for the preparation of side chain-fluorinated alkyloxazoles, wherein hydroxyalkyloxazoles are reacted with an α,α-difluoroalkylamine at pressures of under 2 bar, in the presence of an inert solvent boiling at above 100° C. (at normal pressure), and new fluorinated alkyloxazoles.

All E-10,20-methanoretinoylopsin, light-stable rhodopsin. Synthesis and spectroscopy of all E-10,20-methano- and all-E-retinoyl fluoride and their reaction with bovine opsin

In order to obtain a light-stable rhodopsin as a potential candidate for crystallization and structural X-ray analysis, we synthesized and characterized the novel all E-10,20-methanoretinoyl fluoride (2).This retinal analogue has a locked 11-cis configuration, preventing the light-induced 11-cis -> trans isomerization and binds to opsin by a stable peptide bond rather than a Schiff base. 2 reacted with (methylated) bovine opsin, forming a light- and thermo-stable pigment with λmax at 390 nm.Its opsin shift (2500 cm-1) is in the same order of magnitude as that in rhodopsin (2650 cm-1), suggesting that the mechanism for the red shift is not located in the direct vicinity of the chromophore-protein linkage.We also report the first synthesis and characterization of all-E-retinoyl fluoride (10), which failed to give a pigment on reaction with bovine opsin.

9α, 11β-substituted and 11β-substituted estranes

9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.

N-PERHALOFLUOROALKYLATION OF SECONDARY AMINES BY THE REACTIONS OF THE AMINES AND AMIDES WITH PERHALOFLUOROALKANES. HALOPHILIC ATTACK OF NITROGEN NUCLEOPHILE ON C-Br BOND.

Secondary amines and amides react spontaneously with perhalofluoroalkanes CF2BrCFBrX(X = F, Cl, CF3) to afford N-perhalofluoroalkylated tertiary amines in fair to good yields.Evidence for an anionic chain process initiated by the bromophilic attack of nitrogen nucleophiles on C-Br bonds is given.

N-ALKYLIDENECARBAMOYL ISOCYANATES. REACTION OF TERTIARY α-FLUOROAMINE WITH TRIMETHYLSILYL ISOCYANATE

The reaction of (1,1,2-trifluoro-2-chloroethyl)diethylamine with trimethylsilyl isocyanate gives an adduct (1:2), which in reactions with nucleophilic reagents containing an active hydrogen atom gives derivatives of 2-chloro-2-fluoro-1-(diethylamino)ethylidenecarbamic acid.

1,2,2,2-Tetrafluoroethyl ethers and process for preparing them

1,2,2,2-Tetrafluoroethyl ethers and process for preparing them; the compounds are useful inhalation anesthetics which are distinguished by shorter recovery times.