430-71-7

Basic information

• Product Name: PROPIONYL FLUORIDE
• Synonyms: propanoylfluoride;Propanoyl-fluoride-;PROPIONYL FLUORIDE;Propionylfluoride97%;Propanoic acid fluoride;Propionic acid fluoride;Propanoyl fluoride 97%;Propanoylfluoride97%
• CAS NO: 430-71-7
• Molecular Formula: C₃H₅FO
• Molecular Weight: 76.07
• EINECS: 207-067-7
• Mol File: 430-71-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 43
• Flash Point: 3.2 °C
• Appearance: /
• Density: 0.9720
• Vapor Pressure: 369mmHg at 25°C
• Refractive Index: 1.3290
• CAS DataBase Reference: PROPIONYL FLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPIONYL FLUORIDE(430-71-7)
• EPA Substance Registry System: PROPIONYL FLUORIDE(430-71-7)

Safety Data

• Hazard Codes: C,F
• Statements: 11-34
• Safety Statements: 16-26-36/37/39
• RIDADR: 2924
• HazardClass: FLAMMABLE, CORROSIVE
• Hazardous Substances Data: 430-71-7(Hazardous Substances Data)

Usage

General Description

Propionyl fluoride is a chemical compound with the formula C3H5FO. It is a colorless, flammable liquid that is used in the synthesis of pharmaceuticals and agrochemicals. Propionyl fluoride is also used as a reagent in organic chemistry for the introduction of the propionyl group into various compounds. It is highly reactive and can undergo nucleophilic substitution reactions with a variety of nucleophiles. Just like many other fluorine-containing compounds, propionyl fluoride must be handled and stored with care due to its toxic and corrosive nature.

InChI:InChI=1/C3H5FO/c1-2-3(4)5/h2H2,1H3

Upstream product

• 357-83-5 N-(2-chloro-1,1,2-trifluoroethyl)diethylamine 
• 137-40-6 sodium proprionate 
• 79-03-8 propionyl chloride 
• 802294-64-0 propionic acid 
• 455-32-3 benzoyl fluoride 
• 7789-21-1 fluorosulphonic acid 
• 123-62-6 propionic acid anhydride 
• 400-54-4 propionyltrifluoroacetone 

Downstream Products

• 5337-93-9 4'-methylpropiophenone 
• 1956-06-5 4-nitrophenyl propionate 
• 5827-78-1 N-methyl-N-phenylpropanamide 
• 1114-51-8 N,N-diethylpropanamide 
• 2760-31-8 N-(4-methoxyphenyl)-propanamide 
• 620-71-3 N-(phenyl)-2-methylacetamide 
• 10264-12-7 N-benzylpropanamide 
• 758-96-3 N,N-dimethyl-propanamide 
• 590-18-1 (Z)-2-Butene 
• 591-34-4 s-butyl propionate 
• 624-64-6 trans-2-Butene 
• 359-01-3 2-fluorobutane 
• 108448-63-1 Co₂(CO)6HCCC₆H₉(OCH₂CHCH₂)(COC₂H₅) 
• 14333-26-7 hydrogen fluoride 

Relevant articles and documents

Direct amidation of acid fluorides using germanium amides

Amide functional groups are an essential linkage that are found in peptides, proteins, and pharmaceuticals and new methods are constantly being sought for their formation. Here, a new method for their preparation is presented where germanium amides Ph3GeNR2convert acid fluorides directly to amides. These germanium amides serve to abstract the fluorine atom of the acid fluoride and transfer their amide group -NR2to the carbonyl carbon, and so function as amidation reagents.

MANUFACTURING METHOD OF FLUORINATED HYDROCARBON

PROBLEM TO BE SOLVED: To provide a method for industrially advantageously manufacturing fluorinated hydrocarbon (3). SOLUTION: There is provided a method for manufacturing fluorinated hydrocarbon represented by the formula (3), including contacting a secondary or tertiary ether compound represented by the formula (1) and acid fluoride represented by the formula (2) in the presence of a silver salt in a hydrocarbon solvent. R1 and R2 are each independently a C1 to 3 alkyl group, R1 and R2 may bind to form a ring structure, R3 is H, a methyl group or an ethyl group, R4 and R5 are each independently a methyl group or an ethyl group. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT