357172-73-7

Upstream product

• 25691-80-9 1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propenone 
• 4537-09-1 1,4-dimethoxy-2,3,5-trimethyl-benzene 
• 357172-72-6 3-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-one 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 212579-64-1 (4R)-1-(2,2-dimethyl-[1,3]dioxolan-4-yl)allyl alcohol 
• 69821-05-2 1-bromo-2,5-dimethoxy-3,4,6-trimethylbenzene 
• 700-13-0 Trimethylhydroquinone 
• 357172-71-5 (S)-4-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-2-ol 

Downstream Products

• 69400-39-1 (+) (S)-6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-carbaldhyde 
• 357172-74-8 (S)-6-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,5,7,8-tetramethyl-chroman 

Relevant academic research and scientific papers

A new synthetic route to (S)-chroman aldehyde, a key chiral precursor of vitamin E

A highly stereocontrolled synthetic route to (S)-chroman aldehyde has been developed which starts with trimethyl-p-hydroquinone and (R)-glycerladehyde acetonide and employs as key steps the Michael addition of the aromatic copper species onto the (R)-4-acryloyl-1,3-dioxolane followed by the highly diastereoselective methylation of the resulting ketone adduct.