357262-87-4

Basic information

• Product Name: 1-benzoyl-3-(R)-methyl-4-[(7-chloro-4-azaindol-3-yl)oxoacetyl]piperazine
• CAS NO: 357262-87-4
• Molecular Weight: 410.86
• Mol File: 357262-87-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzoyl-3-(R)-methyl-4-[(7-chloro-4-azaindol-3-yl)oxoacetyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzoyl-3-(R)-methyl-4-[(7-chloro-4-azaindol-3-yl)oxoacetyl]piperazine(357262-87-4)
• EPA Substance Registry System: 1-benzoyl-3-(R)-methyl-4-[(7-chloro-4-azaindol-3-yl)oxoacetyl]piperazine(357262-87-4)

Safety Data

• Hazardous Substances Data: 357262-87-4(Hazardous Substances Data)

Upstream product

• 791053-66-2 (7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-oxo-acetic acid 
• 357263-39-9 1-benzoyl-3-(R)-methylpiperazine 
• 13091-23-1 4-chloro-3-nitropyridine 

Downstream Products

• 1100915-79-4 C₂₂H₂₂N₄O₄ 

Relevant articles and documents

Inhibitors of HIV-1 attachment. Part 10. the discovery and structure-activity relationships of 4-azaindole cores

A series of 4-azaindole oxoacetic acid piperazine benzamides was synthesized and evaluated in an effort to identify an oral HIV-1 attachment inhibitor with the potential to improve upon the pre-clinical profile of BMS-378806 (7), an initial clinical compound. Modifications at the 7-position of the 4-azaindole core modulated potency significantly and SAR showed that certain compounds with a 5-membered ring heteroaryl group at that position were the most potent. Four of the compounds with the best profiles were evaluated in a rat pharmacokinetic model and all had superior oral bioavailability and lower clearance when compared with 7.