357269-94-4Relevant academic research and scientific papers
Oxidation of thiazolo[3,2-a]pyrimidin-3(2H)-ones with DMSO and Lawesson's reagent
Lashmanova, Eugenia A.,Kirdyashkina, Anastasiya I.,Slepukhin, Pavel A.,Shiryaev, Andrey K.
supporting information, p. 1099 - 1103 (2018/02/19)
2,2′-Dimers with a central double bond were prepared by the oxidation of 5,6-disubstituted 7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-ones with DMSO and Lawesson's reagent at room temperature. The role of DMSO as an oxidizing reagent was confirmed by NMR spectroscopy. The E-configuration of the central C[dbnd]C bond for the two diastereomers of compound 8m was proven by single crystal X-ray data. The dimeric thiazolopyrimidines were orange or red colored and absorption bands at 283–330 and 459–476 nm were observed in the UV spectra.
A facile, rapid, one-pot regio/stereoselective synthesis of 2-iminothiazolidin-4-ones under solvent/scavenger-free conditions
Sathishkumar, Murugan,Nagarajan, Sangaraiah,Shanmugavelan, Poovan,Dinesh, Murugan,Ponnuswamy, Alagusundaram
supporting information, p. 689 - 697 (2013/06/05)
A rapid and efficient one pot solvent/scavenger-free protocol for the synthesis of 2-iminothiazolidin-4-ones has been developed. Interestingly, the regio/stereoselective synthesis affords the regioisomeric (Z)-3-alkyl/aryl-2-(2- phenylcyclohex-2-enylimino
