357426-12-1

Basic information

• Product Name: methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate
• Synonyms: methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate;3-(Aminomethyl)-2,3-dihydro-1H-indene-1-carboxylic acid methyl ester;Methyl 3-(aMinoMethyl)indan-1-carboxylate
• CAS NO: 357426-12-1
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.255
• Mol File: 357426-12-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 316.8 °C at 760 mmHg
• Flash Point: 169.1 °C
• Appearance: /
• Density: 1.134
• Vapor Pressure: 0.0004mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate(357426-12-1)
• EPA Substance Registry System: methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate(357426-12-1)

Safety Data

• Hazardous Substances Data: 357426-12-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate is a chemical compound with a complex molecular structure. It contains a methyl group, an aminomethyl group, and a carboxylate group, all attached to a central indene ring. methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate is used in organic synthesis and can be found in pharmaceuticals and agrochemicals. It has potential applications in the pharmaceutical industry due to its ability to serve as a building block for the synthesis of biologically active compounds. Additionally, its structural features make it a versatile intermediate in the production of a variety of different chemical products.

InChI:InChI=1/C12H15NO2/c1-15-12(14)11-6-8(7-13)9-4-2-3-5-10(9)11/h2-5,8,11H,6-7,13H2,1H3

Upstream product

• 474024-38-9 3-[1,3]dioxolan-2-ylidene-3H-indene-1-carbonitrile 
• 67-56-1 methanol 
• 29427-70-1 methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate 
• 29427-69-8 3-oxoindan-1-carboxylic acid 
• 357426-11-0 methyl 3-cyano-3-(trimethylsilanyloxy)indan-1-carboxylate 

Downstream Products

• 357426-13-2 1,5-methano-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine 

Relevant articles and documents

Synthesis of (1-(aminomethyl)-2,3-dihydro-1H-inden-3-yl)methanol: Structural confirmation of the main band impurity found in Varenicline starting material

Described here is the synthesis of (1-(aminomethyl)-2,3-dihydro-1H-inden-3- yl)methanol 1, the previously unidentified impurity found in the synthesis of 2,1 providing a confirmation of the structure. Fabbrica Italiano Sintetici (FIS), working in conjunction with Pfizer Groton, reported an unidentified impurity, referred to as the "main band impurity", in 2 at levels of 0.4 to 0.8%. The structure was postulated to be 1, the open-ring product of the lithium aluminum hydride (LAH) reduction of 3 to 2. Although the cis isomer of 1 was previously reported in the literature,2 a much shorter racemic synthesis was developed using intermediates employed for the production of Varenicline. Several reducing agents were screened for the synthesis of 1, with LiAlH4 followed by basic workup conditions giving optimal results. High performance liquid chromatography (HPLC) analysis ultimately confirmed the structure of 1 as the main band impurity generated during the synthesis of 2. Copyright Taylor & Francis Group, LLC.

A general route to the synthesis of 1,5-methano- and 1,5-ethano-2, 3,4,5-tetrahydro-1h-3-benzazepines

A general approach to preparing 1,5-methano-(1) and l,5-ethano-2,3,4,5- tetrahydro-lff-3-benzazepine (2) is discussed. This strategy involves converting an indanone or tetralone (4) to a cyanohydrin (3) which is subjected to hydrogenolysis followed by lac