Methyl 3-amino-2-hydroxybenzoate

Base Information

• Chemical Name: Methyl 3-amino-2-hydroxybenzoate
• CAS No.: 35748-34-6
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 2922509090
• European Community (EC) Number: 817-266-6
• DSSTox Substance ID: DTXSID20509747
• Wikidata: Q82367587
• Mol file: 35748-34-6.mol

Synonyms:methyl 3-amino-2-hydroxybenzoate;35748-34-6;3-amino-2-hydroxybenzoic acid methyl ester;methyl3-amino-2-hydroxybenzoate;Benzoic acid, 3-amino-2-hydroxy-, methyl ester;MFCD09842614;METHYL 3-AMINOSALICYLATE;methyl 3-amino-2-hydroxy-benzoate;methyl-m-aminosalicylat;Methyl-3-aminosalicylate;SCHEMBL204668;aminohydroxy-benzoic methyl ester;DTXSID20509747;Methyl-3-amino-2-hydroxybenzoate;OMWQHVRUXLRZRC-UHFFFAOYSA-N;BCP21846;AKOS006238132;AB53733;CS-W000705;PS-3104;3-AMINOSALICYLIC ACID METHYL ESTER;AC-23860;SY036497;3-Amino-2-hydroxy-benzoic acid methyl ester;3-anino-2-hydroxy-benzoic acid methyl ester;AM20080679;FT-0735839;EN300-66964;A822971;3-Amino-2-hydroxy methyl benzoic acid methyl ester;W-202470;Z1065729996

Chemical Property of Methyl 3-amino-2-hydroxybenzoate

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 120℃ (dichloromethane )
• Refractive Index: 1.606
• Boiling Point: 274.919 °C at 760 mmHg
• PKA: 9.55±0.10(Predicted)
• Flash Point: 120.067 °C
• PSA: 72.55000
• Density: 1.306 g/cm³
• LogP: 1.34220
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, DMSO, Methanol
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-2-hydroxybenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=C(C(=CC=C1)N)O
• Uses: 3-Amino-2-hydroxybenzoic Acid Methyl Ester is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.

Technology Process of Methyl 3-amino-2-hydroxybenzoate

There total 9 articles about Methyl 3-amino-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-hydroxy-3-nitro-benzoic acid methyl ester (22621-41-6) → methyl 3-aminosalicylate (35748-34-6)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 49h; under 3102.97 Torr;

Reference yield: 99.0%

→ methyl 3-aminosalicylate (35748-34-6)

Guidance literature:

Reference yield: 85.1%

methanol (67-56-1) + 3-aminosalicylic acid (570-23-0) → methyl 3-aminosalicylate (35748-34-6)

Guidance literature:

In dimethyl sulfoxide; at 0 - 60 ℃; for 24h;

upstream raw materials:

methanol

3-aminosalicylic acid

2-hydroxy-3-nitro-benzoic acid methyl ester

methyl 5-bromo-2-hydroxy-3-nitrobenzoate

Downstream raw materials:

dimethyl 2-amino-3-oxo-3H-phenoxazine-4,6-dicarboxylate

2-hydroxy-3-{[2-(2-methoxyphenyl)benzoxazole-7-carbonyl]amino}benzoic acid methyl ester

2-hydroxy-3-(2-methoxybenzoylamino)benzoic acid methyl ester

methyl 2-hydroxy-3-formylaminobenzoate