35750-02-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
1-CHLORO-3-PHTHALIMIDO-2-PROPANONE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to contribute to the development of biologically active compounds.
Used in Organic Synthesis:
1-CHLORO-3-PHTHALIMIDO-2-PROPANONE is used as a building block in organic synthesis for its versatility in creating a wide range of chemical compounds.
Used in Research and Development Laboratories:
1-CHLORO-3-PHTHALIMIDO-2-PROPANONE is used as a reagent in research and development laboratories for its selective reactivity and ability to modify functional groups in complex molecules, which aids in the discovery and optimization of new chemical entities.
Used in Medicinal Chemistry:
1-CHLORO-3-PHTHALIMIDO-2-PROPANONE is used in medicinal chemistry for its potential to contribute to the design and synthesis of new drugs with unique therapeutic properties.
Used in Material Science:
1-CHLORO-3-PHTHALIMIDO-2-PROPANONE is used in material science for its potential applications in the development of new materials with specific properties, leveraging its unique chemical characteristics.

InChI:InChI=1/C11H8ClNO3/c12-5-7(14)6-13-10(15)8-3-1-2-4-9(8)11(13)16/h1-4H,5-6H2

Upstream product

• 19667-37-9 2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione 
• 19791-68-5 1-diazo-3-phthalimidopropan-2-one 
• 5455-98-1 2-oxiranylmethylisoindole-1,3-dione 
• 136918-14-4 phthalimide 
• 4702-13-0 N-phthaloylglycine 
• 6780-38-7 N-phthaloylglycine chloride 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 78-98-8 2-oxopropanal 
• 131920-15-5 6-benzyloxy-4-cyano-4-ethoxycarbonyl-1,2,3,4-tetrahydro-1-amino methylene>carbazole 
• 131920-03-1 6-benzyloxy-4-cyano-4-ethoxycarbonyl-1,2,3,4-tetrahydro-2-amino methylene>carbazole 
• 131920-01-9 5-(5-benzyloxy-3-indolyl)-4-cyano-4-ethoxycarbonyl-1-(N-phthalimidyl)pentan-2-one 
• 131920-02-0 6-benzyloxy-4-cyano-4-ethoxycarbonyl-1H-2,3-dihydro-1-(N-phthalimidyl methylene)carbazole 

Relevant academic research and scientific papers

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Synthesis of New Methanofullerenes with Phthalimide Fragment

Abstract: Bromo- and chloromethyl ketones based on N-phthalyl-substituted amino acids have been synthesized via the Arndt–Eistert reaction. The products [2+1] cycloaddition to the fullerene scaffold has afforded the monoadducts of fullerene C60.

A straightforward and general access to α-phthalimido-α′- substituted propan-2-ones

The regioselective ring opening of the commercially available N-(2,3-epoxypropyl)phthalimide with different nucleophiles, to obtain the corresponding phthalimidopropan-2-ols (including a challenging fluorohydrin) followed by the Dess-Martin periodinane ox

Efficient Horner-Wadsworth-Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones

An intramolecular Horner-Wadsworth-Emmons reaction promoted by KF-Alumina involving a N-substituted phthalimide, cleanly and efficiently furnishes an interesting α,β-unsaturated tricyclic enone which may undergo selective alkylations at the α′-position.

Highly stereoselective reduction of haloketones using three new yeasts: Application to the synthesis of (S)-adrenergic β-blockers related to propranolol

The stereoselective reduction of aryloxy-halo-2-propanones 1 or of 1-chloro-3(phthalimdyl)-propan-2-one 2 using baker's yeast usually displays poor yields and/or ees. Three new yeasts, Saccharomyces bayanus CECT 1317, Yarrowia lipolytica CECT 1240 and Pic

THE CHEMISTRY OF THE PYRIDOCARBAZOLES PART 15. THE SYNTHESIS OF UNSYMMETRICALLY 1,4-DISUBSTITUTED CARBAZOLES AND THEIR USE IN THE SYNTHESIS OF 6H-PYRIDOCARBAZOLES

A new construction of unsymmetrically 1,4-disubstituted carbazoles has been devised and used in the synthesis of the alkaloid olivacine.The starting materials are gramines and the sodium salts of 2-cyano-4-oxopentanonitriles.These afford 4-cyano-5-(indol-