500119-40-4

Basic information

• Product Name: N-(3-aminophenyl)-2-piperidin-1-ylacetamide
• Synonyms: N-(3-aminophenyl)-2-piperidin-1-ylacetamide
• CAS NO: 500119-40-4
• Molecular Formula: C₁₃H₁₉N₃O
• Molecular Weight: 233.30946
• Mol File: 500119-40-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-aminophenyl)-2-piperidin-1-ylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-aminophenyl)-2-piperidin-1-ylacetamide(500119-40-4)
• EPA Substance Registry System: N-(3-aminophenyl)-2-piperidin-1-ylacetamide(500119-40-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 500119-40-4(Hazardous Substances Data)

Upstream product

• 99-09-2 3-nitro-aniline 
• 110-89-4 piperidine 
• 35763-43-0 N-(3-nitrophenyl)-2-(piperidin-1-yl)acetamide 
• 10147-71-4 2-chloro-N-(3-nitrophenyl)acetamide 

Downstream Products

• 1262546-35-9 N-(3-azidophenyl)-2-(piperidin-1-yl)acetamide 
• 1400645-89-7 C₄₀H₄₂N₁₀O₂ 

Relevant articles and documents

A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines

A series of naphthalene derivatives with disubstituted triazole side-arms have been assembled by click chemistry. Lead compounds show a high level of selectivity for renal, osteo- and Ewing's sarcomas that express the HIF-1α transcription factor. They also interact selectively with the quadruplex DNAs located in the promoter of the HIF genes and it is suggested that the mechanism of action involves inhibition of transcription by drug-mediated quadruplex stabilization in these regions.

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

Metasubstituted thiazolidinones, their manufacture and use as a drug

This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.