3577-94-4Relevant academic research and scientific papers
ETHAMBUTOL BASED NITRIC OXIDE DONORS
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Page/Page column 10-11, (2008/06/13)
The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds - diazeniumdiolates nitric oxide donors - that are based on ethambutol possessing physiological and biomedical activity.
Synthesis of N-[1-(chloromethyl)propyl]acetamide
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, (2008/06/13)
N-[1-(Chloromethyl)propyl]acetamide, for the synthesis of ethambutol hydrochloride, d,d'-2,2'-(ethylenediimino)-di-1-butanol dihydrochloride, is produced in high purity and good yields by the reaction of butene-1, a nitrile, preferably an excess of acetonitrile, and chlorine to form N-[1-(chloromethyl)propyl]acetimidoyl chloride which is hydrolyzed to N-[1-(chloromethyl)propyl]acetamide. This may be hydrolyzed further to dl-2-amino-1-butanol, which can be isolated as the hydrochloride, or free base, or a mixture, resolved with L(+)-tartaric acid and the d-2-amino-1-butanol reacted with ethylene dichloride and then hydrochloric acid to form ethambutol hydrochloride.
