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1070-11-7

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1070-11-7 Usage

Chemical Properties

White Powder

Originator

Myambutol,Lederle,US,1967

Uses

Different sources of media describe the Uses of 1070-11-7 differently. You can refer to the following data:
1. Antibacterial (tuberculostatic)
2. Antituberculous
3. Ethambutol dihydrochloride it acts as a tuberculostatic antibacterial agent. It is used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate.

Definition

ChEBI: The dihydrchloride salt of ethambutol. A bacteriostatic antimycobacterial drug, it is effective against Mycobacterium tuberculosis and some other mycobacteria. It is used in combination with other antituberculous drugs in the treatment of pulm nary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol dihydrochloride is used alone.

Manufacturing Process

To 27 grams (2.55 mols) of 2-amino-1-butanol was added 100 grams (1.0 mol) of ethylene dichloride. The mixture was heated at reflux and in a few minutes, the exothermic reaction required the removal of exterior heating. After 10 minutes, exterior heating was recommenced for an additional 20 minutes. The hot mixture was then treated with 300 ml of methanol and then cautiously with 84 grams (2.1 mols) of sodium hydroxide in 80 ml of water.The precipitated sodium chloride was removed by filtration. The excess 2- amino-1-butanol distilled as light yellow oil at 83° to 87°C/13 mm. The viscous residue distilled at 165° to 170°C/0.6 mm as a light yellow oil which tended to solidify in the air condenser; yield, 108 grams.Recrystallization by dissolving in 80 ml of hot ethanol, adding about 150 ml of petroleum ether (BP 90° to 100°C) and cooling at 5°C overnight, gave 64 grams of white crystals melting at 128° to 132.5°C. This, on recrystallization from 100 ml of 95% ethanol, gave 35 grams of white crystals melting at 134.5° to 136°C and a second crop of 10 grams melting at 132.5° to 134°C which is the meso base. Its dihydrochloride melts at 202° to 203°C.From the ethanolic filtrates upon addition of 130 ml of about 4 N ethanolic hydrochloric acid and cooling, there was obtained 55 grams of white crystals melting at 176.5° to 178°C and a second crop of 10 grams melting at 171.5° to 174.5°C. This is the dl racemate dihydrochloride.

Brand name

Myambutol (Stat Trade).

Therapeutic Function

Antitubercular

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.

Clinical Use

Antibacterial agent:Tuberculosis

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

Ethambutol is partially metabolised in the liver to the aldehyde and dicarboxylic acid derivatives, which are inactive.Up to 80% of a dose appears in the urine within 24 hours, 50% as unchanged drug and 8-15% as the inactive metabolites. About 20% of the dose is excreted unchanged in the faeces.

Check Digit Verification of cas no

The CAS Registry Mumber 1070-11-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,7 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1070-11:
(6*1)+(5*0)+(4*7)+(3*0)+(2*1)+(1*1)=37
37 % 10 = 7
So 1070-11-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H24N2O2.ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;/h9-14H,3-8H2,1-2H3;1H/t9-,10-;/m0./s1

1070-11-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (E1011)  (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride  >98.0%(T)

  • 1070-11-7

  • 5g

  • 350.00CNY

  • Detail
  • TCI America

  • (E1011)  (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride  >98.0%(T)

  • 1070-11-7

  • 25g

  • 1,200.00CNY

  • Detail
  • Sigma-Aldrich

  • (E1850000)  Ethambutol hydrochloride  European Pharmacopoeia (EP) Reference Standard

  • 1070-11-7

  • E1850000

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (Y0000803)  Ethambutol for system suitability  European Pharmacopoeia (EP) Reference Standard

  • 1070-11-7

  • Y0000803

  • 1,880.19CNY

  • Detail
  • USP

  • (1257007)  Ethambutol hydrochloride  United States Pharmacopeia (USP) Reference Standard

  • 1070-11-7

  • 1257007-200MG

  • 4,326.66CNY

  • Detail

1070-11-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethambutol dihydrochloride

1.2 Other means of identification

Product number -
Other names Ethambutol hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1070-11-7 SDS

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