35774-47-1

Basic information

• Product Name: Benzene, 1-azido-2-ethyl-
• CAS NO: 35774-47-1
• Molecular Formula: C8H9N3
• Molecular Weight: 147.18
• Mol File: 35774-47-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-azido-2-ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-azido-2-ethyl-(35774-47-1)
• EPA Substance Registry System: Benzene, 1-azido-2-ethyl-(35774-47-1)

Safety Data

• Hazardous Substances Data: 35774-47-1(Hazardous Substances Data)

Upstream product

• 90002-36-1 2-ethylphenyl boronic acid 
• 578-54-1 ortho-ethylaniline 

Downstream Products

• 1452584-39-2 C₁₈H₂₁NO₃ 
• 61653-34-7 1,2-bis(2-ethylphenyl)diazene 
• 5692-66-0 2,2',4,4',6,6'-hexamethylazobenzene 
• 578-54-1 ortho-ethylaniline 
• 1452584-50-7 C₁₇H₁₇NO₃ 
• 204926-79-4 N-butyl-2-ethylphenylamine 
• 155998-59-7 1,3-di-t-butyl-2,2-dimethyl-5,8-di(o-CH₃CH₂-phenyl)-1,3,5,6,7,8-hexaaza-4-germa-2-silaspiro{3.4}oct-6-ene 

Relevant articles and documents

Synthesis and antitumor activity of 1-substituted 1,2,3-triazole-mollugin derivatives

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.

Optimizing the aryl-triazole of cjoc42 for enhanced gankyrin binding and anti-cancer activity

Gankyrin is an oncoprotein overexpressed in numerous cancer types and appears to play a key role in regulating cell proliferation, cell growth, and cell migration. These roles are largely due to gankyrin's protein-protein interaction with the 26S proteaso

Design, combinatorial synthesis and biological evaluations of novel 3-amino-1'-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2'-oxospiro[benzo[a] pyrano[2,3-c]phenazine-1,3'-indoline]-2-carbonitrile antitumor hybrid molecules

A combinatorial chemical library of fifty-nine novel 3-amino-1'-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2'-oxospiro[benzo[a]pyrano[2,3-c]phenazine-1,3'-indoline]-2-carbonitrile, designed as hybrid molecules of phenazine, pyran, indole and 1,2,3-triazole pharmacophores, were constructed in this study. Cytotoxic evaluation indicated that some compounds exhibited moderate cytotoxicity against HCT116, MCF7, HepG2 and A549 cancer cell lines in vitro, in which compound 36 was found to have best antiproliferative activity against the A549 cancer cell line with IC50 value of 5.4 μM. All compounds had low or no effect against L02 and HUVEC non-cancer cell lines. Compound 36 was further confirmed to mainly locate mitochondria in A549 cancer cells via laser-scanning confocal microscopy. Moreover, compound 36 was proved to increase ROS production and induce cell cycle arrest in S phase. Western blot analysis illustrated Bax/Bcl-2 ratio was increased at dose-dependent manner, and both cleaved caspase-3 and cleaved caspase-9 was enhanced by treated with compound 36. All the above evidences in vitro indicated that compound 36 might induce the apoptosis of A549 cancer cells via a mitochondria-dependent pathway.