35779-40-9

Usage

Organic compound

A compound containing carbon atoms, indicating that 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione is an organic compound.

Pyridine and phenyl group

Two heterocyclic rings, pyridine and phenyl, that are attached to the central ethane-1,2-dione moiety, indicating the presence of these functional groups in the structure of 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione.

Diketone

A carbonyl group (C=O) contained twice in the molecule, indicating that 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione contains two carbonyl groups.

Versatile reactivity

The ability of 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione to react with a variety of other compounds, indicating its potential use in the synthesis of other organic compounds.

Pharmaceutical and agrochemical synthesis

The use of 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione in the production of pharmaceuticals and agrochemicals, indicating its practical applications in these fields.

Biological activity and medicinal properties

The potential of 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione to have therapeutic effects, such as anti-inflammatory and antioxidant effects.

Building block

The use of 1-phenyl-2-(pyridin-4-yl)ethane-1,2-dione as a starting material in the synthesis of other organic compounds, indicating its importance in organic synthesis.

Upstream product

• 7446-08-4 selenium(IV) oxide 
• 1620-55-9 1-phenyl-2-(4-pyridinyl)ethanone 
• 2510-22-7 4-pyridylacetylene 
• 591-50-4 iodobenzene 
• 536-74-3 phenylacetylene 
• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 13295-94-8 4-(phenylethynyl)pyridine 

Downstream Products

• 19038-42-7 (1RS,2SR)-1-phenyl-2-[4]pyridyl-ethane-1,2-diol 

Relevant academic research and scientific papers

Sequentially Pd/Cu-Catalyzed Alkynylation-Oxidation Synthesis of 1,2-Diketones and Consecutive One-Pot Generation of Quinoxalines

We report a simple and efficient one-pot synthesis of 1,2-diketones by concatenation of two Pd/Cu-catalyzed processes: Pd0/CuI-catalyzed Sonogashira coupling of terminal alkynes with aryl (pseudo)halides furnishes internal alkynes, which are directly transformed by PdII/CuII-catalyzed Wacker-type oxidation with DMSO and oxygen as dual oxidants to furnish 1,2-diketones. With this efficient, catalyst economical process, various aryl iodides and triflates are efficiently transformed in high yields into symmetrically and unsymmetrically substituted 1,2-diketones with various functional groups. This process can be readily extended to a consecutive one-pot synthesis of quinoxalines in a diversity-oriented fashion.

Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines

A library of star-shaped 2H-imidazolines has been synthesized via Debus-Radziszewski condensation from 1,2-diketones and ketone starting materials. Selective reduction of one imine group of the 2H-imidazole intermediate with LiAlH4 or catalytic flow hydrogenation furnished 2H-imidazolines, which could be conveniently diversified by reacting the amine N with electrophiles, resulting in a set of 21 amide-, carbamate-, urea-, and allylamine-containing products. In total, five points of diversification could be used, which allow the production of a set of functionally diverse compounds. The synthesis of acylated 2H-imidazolidines resulted in intrinsically labile compounds, which spontaneously degraded to acyclic derivatives, as shown for the reaction of 2H-imidazolidine with hexylisocyanate.

Facile preparation of 1,2-diketones

Easily accessible lead-like libraries of heterocyclic molecules useful for high-throughput screening are of continuous interest to the pharmaceutical industry. A number of drug-like libraries are derived from aromatic 1,2-diketones; however, nonsymmetrical 1,2-diketones are challenging to prepare. This communication describes a simple and practical synthesis of 1,2-diketones based on a controlled cross benzoin-like condensation reaction. Copyright Taylor & Francis Group, LLC.

Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation

The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles

PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS

The present invention provides a compound of formula (I) wherein: A represents an optionally substituted monocyclic or polycyclic aryl or heteroaryl group B represents an optionally substituted monocyclic nitrogen-containing heteroaryl group ; and either a) R1 and R2 represent hydrogen or specified substituents, or b) R2, R1 and the -NH- group to which R1 is attached, form a moiety selected from the moiety of formulae (IIa) and (IIb): (IIa) These compounds are useful as antagonists of the A2B receptor, for instance in the treatment of asthma.

OXIDATION OF SUBSTITUTED PYRIDINES PyrCH2X (X=H, COOR, COC6H5) WITH HYPERVALENT IODINE REAGENTS

Oxidation of a variety of pyridines, PyrCH2X (X=H, COOR, COC6H5) with hypervalent iodine reagents PhI(X)(Y) (X=OH, Y=OTs; X=Y=CH3COO; X=Y=CF3COO) has been studied.Simple alkylpyridines are unaffected by the reagents, but 2- and 4-substituted derivatives PyrCH2X (X=COOR, COC6H5) are oxidised at the CH2 group.