35782-30-0Relevant academic research and scientific papers
The facile route to stereodefined alkenyl-substituted pyrimidines
Tan, Jiuqing,Chang, Jianhua,Deng, Minzhi
, p. 3773 - 3783 (2004)
The Suzuki-Miyaura type cross-coupling reactions of various chloropyrimidines with Stereodefined alkenylboronic acids giving the corresponding alkenyl-substituted pyrimidines were studied. The experiments discovered that the reaction is stereospecific and
Method for alkenylation of methyl heterocyclic compound
-
Paragraph 0111-0114, (2021/02/10)
The invention discloses a method for alkenylation of methyl heterocyclic compound, which is a green method for synthesizing an alkenyl heterocyclic compound by carrying out alkenylation reaction on methyl under the condition that the methyl heterocyclic compound and alcohol do not need to participate in a transition metal catalyst. According to the method, alcohol which is cheap, easy to obtain, wide in source, stable and low in toxicity is used as an alkenylation reagent, no transition metal catalyst or ligand is needed, air can be directly used as a convenient, mild and efficient oxidizing agent under the action of common water-soluble inorganic base, and the method is suitable for industrial production. The alkenyl heterocyclic compound is directly synthesized by carrying out a Cenylation reaction with a methyl heterocyclic compound through processes such as oxidative condensation and the like. The method has the advantages of simple reaction conditions, no need of inert gas protection, low requirements on equipment, easiness in operation, water as a byproduct, easiness in removal of water-soluble inorganic base, no metal residue in the product, easiness in purification, suitability for heterocyclic systems such as quinoline, quinoxaline, pyridine, benzothiazole and the like, and wide application range, thereby having certain research significance and potential application prospect.
Aryl-Nickel-Catalyzed Benzylic Dehydrogenation of Electron-Deficient Heteroarenes
Zhang, Pengpeng,Huang, David,Newhouse, Timothy R.
supporting information, p. 1757 - 1762 (2020/02/04)
This manuscript describes the first practical benzylic dehydrogenation of electron-deficient heteroarenes, including pyridines, pyrazines, pyrimidines, pyridazines, and triazines. This transformation allows for the efficient benzylic oxidation of heteroarenes to afford heterocyclic styrenes by the action of nickel catalysis paired with an unconventional bromothiophene oxidant.
Preparation of Vinyl Arenes by Nickel-Catalyzed Reductive Coupling of Aryl Halides with Vinyl Bromides
Liu, Jiandong,Ren, Qinghua,Zhang, Xinghua,Gong, Hegui
supporting information, p. 15544 - 15548 (2016/12/09)
This work emphasizes the synthesis of substituted vinyl arenes by reductive coupling of aryl halides with vinyl bromides under mild and easy-to-operate nickel-catalyzed reaction conditions. A broad range of aryl halides, including heteroaromatics, and vinyl bromides were employed to yielding products in moderate to excellent yields with high functional-group tolerance. The nickel-catalytic system displays good chemoselectivity between the two C(sp2)-halide coupling partners, thus demonstrating a mechanistic pathway distinct from other stepwise protocols.
SYNTHESIS OF PYRIMIDINYL TRIFLATES AND PALLADIUM-CATALYZED COUPLING WITH ORGANOTIN AND ORGANOZINC REAGENTS
Sandosham, Jessie,Undheim, Kjell
, p. 501 - 514 (2007/10/02)
Pyrimidinyl triflates have been synthesized from pyrimidinones using triflic anhydride in the presence of triethylamine.The triflates, in the pyrimidine electrophilic positions, are versatile intermediates for substitution reactions.Carbon substituents ar
Stannylation in the Electrophilic 2- and 4/6-Pyrimidine Position and the Use of Stannylpyrimidines in Coupling and Tin-Lithium Exchange Reactions
Sandosham, Jessie,Undheim, Kjell
, p. 275 - 284 (2007/10/02)
2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines.Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetallation.Tin-lithium exchange in the 2-position
