31519-62-7

Usage

Uses

Used in Pharmaceutical Synthesis:
Pyrimidine-2-carboxylic acid is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its chemical structure allows it to be a key component in the synthesis of drugs targeting different medical conditions.
Used in the Chemical Industry:
In the chemical industry, Pyrimidine-2-carboxylic acid is utilized as a starting material for the production of various chemical compounds, including those with potential applications in agriculture, materials science, and other fields.
Used in Research and Development:
Pyrimidine-2-carboxylic acid is also employed in research and development settings, where it is used to study the properties and potential applications of new compounds and materials. Its versatility as a synthetic intermediate makes it a valuable tool for scientists and researchers working on innovative projects.

InChI:InChI=1/C5H4N2O2/c8-5(9)4-6-2-1-3-7-4/h1-3H,(H,8,9)

Upstream product

• 37131-87-6 5-bromo-2-pyrimidinecarboxylic acid 
• 35782-30-0 2-(β-styryl)pyrimidine 
• 5053-43-0 2-methylpyrimidine 
• 89166-80-3 5-bromo-2-tribromomethyl-pyrimidine 
• 14080-23-0 2-cyanopyrimidine 

Downstream Products

• 62846-82-6 ethyl pyrimidine-4-carboxylate 
• 34253-03-7 pyrimidine-2-carboxylic acid methyl ester 
• 155957-34-9 methyl 2-[(4,4-difluoro-3-butenyl)thio]-4-pyrimidinecarboxylate 
• 1032350-08-5 tert-butyl {1-[4-(9-phenyl-3-pyrimidin-2-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]cyclobutyl}carbamate 
• 1093114-80-7 ethyl β-oxo-2-pyrimidininepropanoate 
• 1144033-63-5 2-[4-methyl-5-(methylthio)-4H-1,2,4-triazol-3-yl]pyrimidine 
• 1064707-04-5 N-[1-(4-{[(4-fluorobenzyl)amino]carbonyl}-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1-methylethyl]pyrimine-2-carboxamide 
• 1196508-29-8 N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidine-2-carboxamide 
• 1198168-42-1 N-(2-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridin-8-yl)pyrimidine-2-carboxamide 
• 1261242-58-3 C₂₀H₂₃ClN₄O₂ 
• 1120368-20-8 C₂₁H₁₄N₆O 
• 1174538-74-9 C₅H₃N₅O 
• 1499572-61-0 N-phenylpyrimidine-2-carboxamide 
• 1575753-19-3 C₁₅H₁₆N₄O₂ 

Relevant academic research and scientific papers

Synthesis, characteristics and photoluminescent properties of novel Ir-Eu heteronuclear complexes containing 2-carboxyl-pyrimidine as a bridging ligand

Two novel iridium(iii) complexes, [Ir(dfppy)2(pmc)] and [Ir(ppy)2(pmc)] (dfppy = 2-(4′,6′-difluoro-phenyl) pyridine, ppy = 1-phenyl-pyridine), were designed and synthesized using 2-carboxyl-pyrimidine (Hpmc) as an ancillary ligand. Single crystals were obtained and characterized by single crystal X-ray diffraction. The tetrametallic complexes {[(CN)2Ir(μ-pmc)]3EuCl 3} (CN = dfppy, ppy) were synthesized using the iridium(iii) complexes as "ligands". Photophysical and theoretical studies indicate that [Ir(dfppy)2(pmc)] is more suitable for sensitizing the emission of Eu(iii) ions than [Ir(ppy)2(pmc)]. The Royal Society of Chemistry.

High hydroxide conductivity in a chemically stable crystalline metal-organic framework containing a water-hydroxide supramolecular chain

A chemically stable cationic MOF encapsulating an in situ formed water-hydroxide supramolecular anionic chain is realized for high hydroxide (OH-) ion conductivity in the solid-state (Type A). High OH- ion conductivity and low activation energy of the MOF demonstrate the advantage of the in situ incorporation of OH- ions to achieve efficient OH- ion conduction in the solid-state.

Tuning spin-crossover transition temperatures in non-symmetrical homoleptic meridional/facial [Fe(didentate)3]2+complexes: what for and who cares about it?

The [FeN6] chromophores found in [Fe(didentate)3]2+complexes, where didentate is a non-symmetrical 2-(6-membered-heterocyclic ring)-benzimidazole ligand (Lk), exist as mixtures of two geometricalmer(C1-symmetry) andfac(C3-symmetry) isomers. Specific alkyl-substituted six-membered heterocyclic rings connected to the benzimidazole unit (pyridines in ligandsL1-L3, pyrazines inL4-L5and pyrimidines inL6-L7) control the ligand field strength and the electron delocalization so that [FeII(Lk)3]2+display tunable thermally-induced spin transitions in solution. Thermodynamic, spectroscopic (UV-Vis, NMR) and magnetic studies in solution demonstrate that [Fe(L6)3]2+(L6= 1-methyl-2-(pyrimidin-2-yl)-1H-benzo[d]imidazole) exhibits a close to room temperature spin transition (T1/2= 273(3) K) combined with a high stability formation constant n acetonitrile), which makes this complex suitable for the potential modulation of lanthanide-based luminescence in polymetallic helicates. A novel method is proposed for assigning specific thermodynamic spin crossover parameters tofac-[Fe(L6)3]2+andmer-[Fe(L6)3]2+isomers in solution. The observed difference relies mainly on the entropic content ΔSmerSCO? ΔSfacSCO= 11(1) J mol?1K?1, which favors the spin transition for the meridional isomer. Intermolecular interactions occurring in the crystalline state largely overcome minor thermodynamic trends operating in diluted solutions and a single configurational isomer is usually observed in the solid state. Among the thirteen solved crystal structures1-13containing the [M(Lk)3]2+cations (M = Fe, Ni, Zn,Lk=L6-L7), pure meridional isomers are observed six times, pure facial isomers also six times and a mixture (44%merand 56%fac) is detected only once. Solid-state magnetic data recorded for the FeIIcomplexes show the operation of slightly cooperative spin transitions in7(fac-[Fe(L6)3]2+) and12(mer-[Fe(L7)3]2+). For the meridional isomer in6, a two-step spin state transition curve, associated with two phase transitions, is detected.

Asymmetric zinc porphyrin derivatives bearing three pseudo-pyrimidine: Meso -position substituents and their photosensitization for H2evolution

Novel asymmetric zinc porphyrin derivatives (ZnPy-5 and ZnPy-6) with meso-positions bearing one benzoic acid and three pseudo-pyrimidines with two N atoms located at different positions were synthesized and utilized as sensitizers for Pt-loaded g-C3N4 (PCN). Compared to the analogue (ZnPy-1 bearing one benzoic acid and three phenyl meso-position substituents), ZnPy-5 and ZnPy-6 exhibit significantly enhanced photosensitization on PCN under visible light (λ ≥ 420 nm) illumination. In particular, ZnPy-5/PCN and ZnPy-6/PCN exhibit H2 evolution activities of 418 and 585 μmol h-1, corresponding to turnover numbers (TON) of 8845 and 12?381 h-1, respectively. Both of these values are much better that (316 μmol h-1) of ZnPy-1/PCN, which has a TON of 6687 h-1. In addition, ZnPy-5/PCN and ZnPy-6/PCN show apparent quantum yields of 32.6% and 33.1% at 420 nm monochromatic light, and these are much higher than that (10.6%) for ZnPy-1/PCN. Compared with ZnPy-5, the two N atoms of the pseudo-pyrimidines in ZnPy-6 are further away from the porphyrin macrocycle, which can more effectively combine with the sacrificial reagent and g-C3N4, thus promoting dye regeneration and the photoexcited charge transfer for delivering better photocatalytic performance. The present results demonstrate that the number and positions of the N atoms in the peripheral substituents of the porphyrin derivatives have a great influence on the photosensitization, and that the fine-tuning of molecular structures is crucial for improving the H2 evolution activity of the dye-sensitized semiconductors.

Solvent Polarity Predictably Tunes Spin Crossover T1/2 in Isomeric Iron(II) Pyrimidine Triazoles

Two isomeric pyrimidine-based Rdpt-type triazole ligands were made: 4-(4-methylphenyl)-3-(2-pyrimidyl)-5-phenyl-4H-1,2,4-triazole (L2pyrimidine) and 4-(4-methylphenyl)-3-(4-pyrimidyl)-5-phenyl-4H-1,2,4-triazole (L4pyrimidine). When reacted with [FeII(pyridine)4(NCE)2], where E = S, Se, or BH3, two families of mononuclear iron(II) complexes are obtained, including six solvatomorphs, giving a total of 12 compounds: [FeII(L2pyrimidine)2(NCS)2] (1), [FeII(L2pyrimidine)2(NCSe)2] (2), 2·1.5H2O, [FeII(L2pyrimidine)2(NCBH3)2]·2CHCl3 (3·2CHCl3), 3 and 3·2H2O, [FeII(L4pyrimidine)2(NCS)2] (4), 4·H2O, [FeII(L4pyrimidine)2(NCSe)2] (5), 5·2CH3OH, 5·1.5H2O, and [FeII(L4pyrimidine)2(NCBH3)2]·2.5H2O (6·2.5H2O). Single-crystal X-ray diffraction reveals that the N6-coordinated iron(II) centers in 1, 2, 3·2CHCl3, 4, 5, and 5·2CH3OH have two bidentate triazole ligands equatorially bound and two axial NCE co-ligands trans-coordinated. All structures are high spin (HS) at 100 K, except 3·2CHCl3, which is low spin (LS). Solid-state magnetic measurements show that only 3·2CHCl3 (T1/2 above 400 K) and 5·1.5H2O (T1/2 = 110 K) undergo spin crossover (SCO); the others remain HS at 300-50 K. When 3·2CHCl3 is heated at 400 K it desorbs CHCl3 becoming 3, which remains HS at 400-50 K. UV-Vis studies in CH2Cl2, CHCl3, (CH3)2CO, CH3CN, and CH3NO2 solutions for the BH3 analogues 3 and 6 led to a 6:1 ratio of Lnpyrimidine/Fe(II) being employed for the solution studies. These revealed SCO activity in all five solvents, with T1/2 values for the 2-pyrimidine complex (247-396 K) that were consistently higher than for the 4-pyrimidine complex (216-367 K), regardless of solvent choice, consistent with the 2-pyrimidine ring providing a stronger ligand field than the 4-pyrimidine ring. Strong correlations of solvent polarity index with the T1/2 values in those solvents are observed for each complex, enabling predictable T1/2 tuning by up to 150 K. While this correlation is tantalizing, here it may also be reflecting solvent-dependent speciation - so future tests of this concept should employ more stable complexes. Differences between solid-state (ligand field; crystal packing; solvent content) and solution (ligand field; solvation; speciation) effects on SCO are highlighted.

Electron-deficient heteroarenium salts: An organocatalytic tool for activation of hydrogen peroxide in oxidations

A series of monosubstituted pyrimidinium and pyrazinium triflates and 3,5-disubstituted pyridinium triflates were prepared and tested as simple catalysts of oxidations with hydrogen peroxide, using sulfoxidation as a model reaction. Their catalytic efficiency strongly depends on the type of substituent and is remarkable for derivatives with an electron-withdrawing group, showing reactivity comparable to that of flavinium salts which are the prominent organocatalysts for oxygenations. Because of their high stability and good accessibility, 4-(trifluoromethyl)pyrimidinium and 3,5-dinitropyridinium triflates are the catalysts of choice and were shown to catalyze oxidation of aliphatic and aromatic sulfides to sulfoxides, giving quantitative conversions, high preparative yields and excellent chemoselectivity. The high efficiency of electron-poor heteroarenium salts is rationalized by their ability to readily form adducts with nucleophiles, as documented by low pKR+ values (pKR+ red > -0.5 V). Hydrogen peroxide adducts formed in situ during catalytic oxidation act as substrate oxidizing agents. The Gibbs free energies of oxygen transfer from these heterocyclic hydroperoxides to thioanisole, obtained by calculations at the B3LYP/6-311++g(d,p) level, showed that they are much stronger oxidizing agents than alkyl hydroperoxides and in some cases are almost comparable to derivatives of flavin hydroperoxide acting as oxidizing agents in monooxygenases.

NEAR-INFRARED-RAY-ABSORBING COMPOSITION, NEAR-INFRARED-RAY CUT FILTER USING SAME, MANUFACTURING METHOD THEREFOR, CAMERA MODULE, AND MANUFACTURING METHOD THEREFOR

Provided are a near-infrared-ray-absorbing composition having strong near-infrared shielding properties when a cured film is produced, a near-infrared-ray cut filter, a manufacturing method therefor, a camera module, and a manufacturing method therefor. The near-infrared-ray-absorbing composition includes a copper complex obtained by reacting a compound (A) having at least two coordination sites with a copper component.

COMPOUNDS AND RELATED COMPOSITIONS AND METHODS OF USE

Compounds and compositions, which can be use for example, for treating cancer, are described herein.

Optically active pyridylethanol derivative

A novel optically active pyridylethanol derivative having a high twistability and also a superior temperature characteristic is provided, which derivative is expressed by the formula STR1 wherein R is an alkyl group of alkoxy group each of 1 to 20 carbon atoms or hydrogen atom, m and n each represent 0 or 1, STR2 each independently represent STR3 wherein Y is any one of H, halogen atom or CN and STR4 is a pyridine ring the N atom of which may be present at an optionally chosen site thereof.