357952-79-5Relevant articles and documents
Diastereoselective Alkene Hydroesterification Enabling the Synthesis of Chiral Fused Bicyclic Lactones
Shi, Zhanglin,Shen, Chaoren,Dong, Kaiwu
supporting information, p. 18039 - 18042 (2021/11/16)
Palladium-catalysed diastereoselective hydroesterification of alkenes assisted by the coordinative hydroxyl group in the substrate afforded a variety of chiral γ-butyrolactones bearing two stereocenters. Employing the carbonylation-lactonization products as the key intermediates, the route from the alkenes with single chiral center to chiral THF-fused bicyclic γ-lactones containing three stereocenters was developed.
Regioselective three-component synthesis of 1,2-diarylindoles from cyclohexanones, α-hydroxyketones and anilines under transition-metal-free conditions
Li, Cheng,Xie, Yanjun,Xiao, Fuhong,Huang, Huawen,Deng, Guo-Jun
supporting information, p. 4079 - 4082 (2019/04/25)
A facile method for the one-pot synthesis of 1,2-diarylindoles under transition-metal-free conditions is described. Cyclohexanones were used as the aryl sources via the dehydrogenative aromatization process. One C-C and two C-N bonds were selectively formed via a domino reaction. This protocol provides a convenient approach for the construction of valuable bioactive 1,2-diarylindoles from readily available cyclohexanones, α-hydroxyketones and anilines.
Facile synthesis of polysubstituted cyclopropanes using α-tosyloxyketones
Rana, Neena,Nain, Sonia,Kumar, Dinesh,Kumar, Ravi
, p. 505 - 507 (2018/02/09)
A facile synthesis of polysubstituted cyclopropanes (5) by the treatment of pyridinium ylides, generated in situ from pyridinium toslyates (2), with arylidenemalonitrile (4) is presented. Pyridinium toslyates (2) were obtained by reacting α-tosyloxyketone
Metal-free C(sp3)-H bond sulfonyloxylation of 2-alkylpyridines and alkylnitrones
Wang, Chang-Sheng,Dixneuf, Pierre H.,Soulé, Jean-Fran?ois
, p. 4954 - 4957 (2018/07/25)
Pyridin-2-ylmethyl tosylate derivatives are obtained in high yields from 2-alkylpyridine 1-oxides via a [3,3]-sigmatropic rearrangement of the adduct between 2-alkylpridine 1-oxides with benzenesulfonyl chlorides. Moreover, alkylnitrones also undergo [3,3]-sigmatropic rearrangement to give α-tosylated ketones after hydrolysis. Substitution reactions with nucleophiles then lead to diverse useful functionalizations for the synthesis of pincer ligands.
A convenient [hydroxy(tosyloxy)iodo]benzene-mediated one-pot synthesis of 2-arylimidazo[2,1-b[benzothiazoles
Sumran, Garima,Aggarwal, Ranjana
, p. 170 - 177 (2015/10/20)
Several 2-arylimidazo[2,1-b]benzothiazoles (4) have been conveniently synthesized in one-pot reactions via α-tosyloxylation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene 2 in acetonitrile, followed by treatment with 2-amino-6-(substituted
Modified one-pot multicomponent diastereoselective synthesis of trans-2,3-Dihydrofuro[3,2-c]coumarins via in situ-generated α- tosyloxyketones
Kumar, Ravi,Wadhwa, Deepak,Hussain, Khalid,Prakash, Om
, p. 1802 - 1807 (2013/05/22)
A modified protocol for diastereoselective synthesis of differently substituted trans-2,3-dihydrofuro[3,2-c]coumarins is developed via, a one-pot multicomoponent reaction starting from aromatic aldehydes, 4-hydroxycoumarin, and α-tosyloxyacetophenones wit
An iodobenzene-catalysed domino route toward quinoxaline derivatives from simple ketones and o-phenylenediamines in one pot
Li, Xiaoqing,Zhou, Can,Hu, Zhiyan,Xu, Xiangsheng
, p. 579 - 581 (2013/10/22)
An iodobenzene-catalysed domino route to quinoxalines from ketones and o-phenylenediamines in one pot has been developed. This transformation consisted of the generation of Koser's generation, α-tosyloxylation of ketones, nucleophilic substitution and intramolecular dehydration with o-phenylenediamines, and dehydrogenation. Website
Catalytic, asymmetric, interrupted Feist-Benary reactions of α-tosyloxyacetophenones
Calter, Michael A.,Korotkov, Alexander
supporting information; experimental part, p. 6328 - 6330 (2012/01/11)
A new variant of the Interrupted Feist-Benary (IFB) reaction uses α-tosyloxyacetophenones as electrophiles and proceeds in good yields and excellent enantioselectivities.
Iodobenzene-catalyzed synthesis of α-azidoketones and α-thiocyanatoketones from aryl ketones with MCPBA as a cooxidant
Chang, Ya-Li,Chung, Chi-Lin,Wu, Fang-Wen,Wang, Huey-Min,Hou, Rei-Sheu,Kang, Iou-Jiun,Chen, Ling-Ching
experimental part, p. 149 - 152 (2011/04/16)
Iodobenzene-catalyzed synthesis of α-azidoketones and α-thiocyanatoketones from aryl ketones with MCPBA as a cooxidant is described. The method is simple, rapid and practical, generating α-azidoketones and α-thiocyanatoketones from the aryl ketone without
Iodobenzene-catalyzed synthesis of imidazo[1,2-a]pyridines from aryl ketones with mCPBA in ionic liquid
Chang, Ya-Li,Wang, Huey-Min,Hou, Rei-Sheu,Kang, Iou-Jiun,Chen, Ling-Ching
experimental part, p. 153 - 156 (2011/04/16)
Iodobenzene-catalyzed synthesis of imidazo[1,2-a]pyridines from aryl ketones with mCPBA as a cooxidant in ionic liquid is described. The method is simple, rapid and practical, generating Imidazo[1,2-a]pyridines from the aryl ketone without isolation of α-