110960-41-3

Basic information

• Product Name: 4-(4-fluorophenyl)-2-imino-3-phenyl-2,3-dihydrothiazole
• CAS NO: 110960-41-3
• Molecular Weight: 270.33
• Mol File: 110960-41-3.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-fluorophenyl)-2-imino-3-phenyl-2,3-dihydrothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluorophenyl)-2-imino-3-phenyl-2,3-dihydrothiazole(110960-41-3)
• EPA Substance Registry System: 4-(4-fluorophenyl)-2-imino-3-phenyl-2,3-dihydrothiazole(110960-41-3)

Safety Data

• Hazardous Substances Data: 110960-41-3(Hazardous Substances Data)

Upstream product

• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 103-85-5 monophenylthiourea 
• 357952-79-5 1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 

Downstream Products

• 110960-42-4 4-(4-fluorophenyl)-3-phenyl-2-trifluoroacetylimino-2,3-dihydrothiazole 

Relevant articles and documents

Effect of substituents on the regioselectivity of the reaction of α-tosyloxyketones with thioureas in acidic medium: Access to 2-aminothiazoles and 2-imino-2,3-dihydrothiazoles

Regioselective condensation of α-tosyloxyacetophenones 1 and N-substituted thioureas 2 in acidic medium to give regioisomers 2-aminothiazoles I and 2-imino-2,3-dihydrothiazoles II is largely influenced by the substituents present on 1 and 2. A mechanism,

The Hantzsch Thiazole Synthesis under Acidic Conditions: Change of Regioselectivity

The condensation of α-halogeno ketones with N-monosubstituted thioureas in neutral solvent leads exclusively to 2-(N-substituted amino)thiazoles.In the present work it was shown that under acidic conditions mixtures of 2-(N-substituted amino)thiazoles and 3-substituted 2-imino-2,3-dihydrothiazoles are formed. (The isomers were distinguished by characteristic differences between their 5-H 1H n.m.r. signals and the i.r.CO bands of their trifluoroacetate derivatives.) The proportions of the 2-imino-2,3-dihydrothiazoles in the mixtures are influenced by experimental features and by the structures of the starting materials.Reactions in 10 M-HCl-EtOH (1:2) at 80 deg C for 20 min were found to be the most efficient for generating 2-imino-2,3-dihydrothiazoles; in the most favourable case 2-imino-3,4-dimethyl-2,3-dihydrothiazole was obtained in 73 percent yield.A possible explanation of the results is discussed.