35817-27-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethoxycoumarin is used as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to be used in the preparation of 2-substituted-6-(2-hydroxyphenyl)-4(3H)-pyrimidones makes it a valuable component in the development of new drugs.
Used in Chemical Synthesis:
In the field of organic chemistry, 4-Ethoxycoumarin is used as a starting material for the synthesis of various chromanone derivatives, such as 2,2-diphenyl-4-chromanone and 2,2-dimethyl-4-chromanone. These compounds have potential applications in different industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C11H10O3/c1-2-13-10-7-11(12)14-9-6-4-3-5-8(9)10/h3-7H,2H2,1H3

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 75-03-6 ethyl iodide 
• 141-52-6 sodium ethanolate 
• 4438-85-1 3H-chromene-2,4-dione 
• 64-17-5 ethanol 
• 17831-88-8 4-chloro-2H-1-benzopyran-2-one 

Downstream Products

• 100976-51-0 1-(2-hydroxy-phenyl)-3-(2-oxo-cyclohexyl)-propane-1,3-dione 
• 3780-21-0 2,2-diphenylchroman-4-one 
• 101093-73-6 2-(2-oxo-cyclohexyl)-chromen-4-one 

Relevant academic research and scientific papers

N-Methylimidazole-mediated synthesis of aryl alkyl ethers under microwave irradiation and solvent free conditions

A microwave-assisted three-component reaction was established for the synthesis of aryl alkyl ethers. The reaction was performed under solvent-free conditions in the presence of N-methylimidazole and dialkyl acetylene-dicarboxylate to furnish a novel approach to O-alkylation of phenol derivatives in high yield.

Indium(0)-mediated Csp 3-S/O cross-coupling approach towards the regioselective alkylation of α-enolic esters/dithioesters: A mechanistic Insight

We have reported an indium(0)-mediated Csp3-S/O cross-coupling approach that leads to the highly regioselective alkylation of α-enolic acetate/dithioacetate systems. This hetero cross-coupling reaction does not require additional co-catalyst or promoter, and the in situ generated organoindium species promotes the reaction by acting as the coupling partner of the α-enolic acetate/dithioacetate substrates. The excellent selectivity for C-, S-, or O-alkylation is solely dependent on the nucleophilic behavior of α-enolic acetate/dithioacetate systems. These results were further supported by DFT calculations of the relative electronic energies of the substrates and products as well as the activation barriers of the respective transformations.